摘要
3,5-二甲氧基氯苄与对苄氧基苯甲醛经格氏反应、固体酸催化剂NaHSO4·SiO2催化脱水制得中间体(E)-3,5-二甲氧基-4'-苄氧基二苯乙烯,再经Pd/Al-MCM-41介孔分子筛催化氢化脱苄制得紫檀茋,总收率为77%。
Pterostilbene was synthesized from 3,5-dimethoxy benzyl chloride and 4-benzyloxybenzaldehyde by Grignard reaction, catalytic dehydration with solid acid NaHSO4＂SiO2 to obtain the intermediate （E）-3,5-dimethoxy-4＇- benzyloxystilbene, followed by debenzylation in the presence of hydrogen and mesoporous molecular sieve Pd-grafted A1-MCM-41 with the overall yield of about 77 %.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2014年第9期816-817,839,共3页
Chinese Journal of Pharmaceuticals
基金
浙江省重点科技创新团队项目(2010R50017)
