生物样品中毒品代谢标志物检测的研究进展

Research Progress in Detecting Drug Metabolic Markers in Biological Samples

毒品在人体内会代谢生成多种代谢产物,这些毒品本身和(或)其代谢产物可以作为毒品滥用人群生物样品的检测标志物。应用高效液相色谱、气相色谱及色谱-质谱联用技术等手段检测不同的毒品代谢标志物,可以鉴别涉毒人员滥用毒品的种类和涉毒时间。本文着重介绍了吗啡类、大麻类、可卡因、苯丙胺类和氯胺酮毒品在人体内的代谢标志物,综述了这些标志物在不同生物样本中的检测方法和研究进展。

Drugs can form a variety of metabolites in metabolic processes in vivo. These drugs themselves and/or their metabolites can be used as markers to detect drug abuse population in biological samples. Some analytical techniques such as HPLC, GC, LC-MS and GC-MS methods are used to detect different drug metabolic markers, which can identify the type and time of drug-related personnel＇s abuse of drugs. In this paper, the metabolic markers of morphine, cannabis, cocaine, amphetamines and ketamine in vivo were summarized. This paper also introduced the detection methods and research progress of these metabolic markers in a variety of biological samples.