顺铂耐药的分子机制及中药干预的研究进展

Advance in studies on molecular mechanisms of cisplatin resistance and intervention with traditional Chinese medicines

顺铂是临床上广泛应用的一线抗癌药物,但顺铂耐药性的产生降低了顺铂的疗效。顺铂是一种细胞周期非特异性药物,其主要作用靶点是细胞内具有亲核性的蛋白质、DNA和RNA。顺铂耐药机制是多因素的,其中转运蛋白的异常表达、细胞内解毒作用的增强、DNA修复能力的增加以及细胞凋亡受阻是顺铂耐药的主要机制。中药在肿瘤治疗中具有独特的优势,中药与顺铂联用能够提高疗效。该文对顺铂耐药的机制和近年来中药与顺铂联合应用的研究进展进行综述。

Cisplatin is a firs-line anticancer drug widely used in clinic. However, its resistance reduces its efficacy. With a non-specific cell cycle, cisplatin＇s main targets are nucleophilic protein, DNA and RNA in cells. Among cisplatin＇s multi-factorial resistance mechanisms, abnormal expression of transport protein, intracellular detoxification enhaancement, DNA repair capacity increase and apoptosis blocking are the main mechanisms. Because traditional Chinese medicines （TCMs） have unique advantages in cancer treatment, their combination with cisplatin can improve the efficacy. In this paper, the authors summarized the advance in studies on cisplatin＇s resistance and the combination of TCMs and cisplatin in recent years.