中西医结合综合治疗儿童手足口病临床研究

Clinical Study of Using Integrative Medicine to Synthetically Treat Hand-foot-and-mouth Disease of Children

目的:观察中西医结合综合治疗儿童手足口病的疗效,探讨手足口病的治疗方案。方法:将患儿分A组336例,予利巴韦林治疗;B组325例,予喜炎平、辨证论治中药内服外洗治疗;C组321例,予A组及B组综合治疗。伴口腔溃疡者,A、B组均予西瓜霜喷剂喷涂,C组联合亚叶酸钙喷涂。比较各组退热时间、疱疹消退时间、口腔溃疡愈合时间、平均留观时间及临床疗效。结果 A、B组在口腔溃疡愈合时间,平均留观时间及临床疗效,差异无统计学意义(P>0.05),但在退热时间、皮疹消退时间B组与A组比较,差异有统计学意义(P<0.05);C组各项指标及临床疗效均优于A、B组,有显著性差异(P<0.01)。结论:中西医结合综合治疗儿童手足口病疗效显著,重症发生率低,是治疗优选方案,值得推广。

Objective ： To observe the therapeutic effect of integrative medicine for hand-foot-and-mouth disease in children and to explore the treatment on it. Method： The cases were randomly divided into three groups. Group A （n = 336） was treated with Ribavirin; group B （ n = 325 ） was treated with Xiyanpine and differentiation of syndromes combined with oral use and wash- ing with herbal medicine; group C （n=321） was treated with the combination method of group A and group B. To the patients accompanied with oral ulcers, they would be treated with Guilin Watermelon Frost in group A and B, while treated with com- bined Leucovorin in group C. The time on fever, hand foot mouth tetter and mouth herpes subsidizing, in-hospital and the thera- peutic effects were compared in different groups. Results： There was no difference on healing period of oral ulcers, in-hospital time and the therapeutic effect （ P〉0. 05 ）. While compared group A with group B, there were differences in the time of fever and the rash subsiding （P〈0. 05 ） ; all the indexes in group C were better than that in group A and B, and the statistical differ ence was significant （ P〈0. 01 ）. Conclusions ： The study demonstrates that the combined therapy of traditional Chinese and western medicine is an effective treatment for hand-foot-and-mouth disease in children, the seriousness rate was low. It is the better method to be chosen for hand-foot-and-mouth disease, thereby deserves further popularization.