仙灵骨葆胶囊治疗膝骨性关节炎的有效性和安全性系统评价

Therapeutic Efficacy and Safety of Xianling Gubao Capsule for Knee Osteoarthritis:A Systematic Review

目的:系统评价仙灵骨葆胶囊治疗膝骨性关节炎(KOA)的有效性和安全性。方法:计算机检索PubMed、OVID、Cochrane Library、中国生物医学文献光盘数据库、中国知网、维普网及万方数据库,收集仙灵骨葆胶囊联合常规疗法与单纯常规疗法疗效比较的临床随机对照试验,对纳入文献进行质量评价;使用RevMan 5.2软件进行Meta分析。结果:本研究纳入文献12篇,共1 390例患者。仙灵骨葆胶囊联合常规疗法的治愈率[RR=1.91,95%CI(1.59,2.29),P=0.005]、总有效率[RR=1.19,95%CI(1.14,1.25),P=0.85]均优于常规疗法;两种疗法不良反应发生率[RR=0.58,95%CI(0.18,1.90),P=0.63]差异无统计学意义。结论:仙灵骨葆胶囊治疗KOA有效,不良反应发生率与常规疗法相当。由于纳入研究质量总体不高,该结论尚需严格设计的高质量、大样本随机对照试验证实。

OBJECTIVE：To evaluate the effectiveness and safety of Xianling gubao capsule（XLGB）for knee osteoarthritis（KOA）. METHODS：Retrieved from PubMed,OVID,Cochrane Library,CBM,CNKI,VIP and Wanfang database,RCTs about XLGB combined routine therapy vs. routine therapy alone for KOA were collected;the quality of included literatures was evaluated. Meta-analysis was conducted by using Review Manager 5.2 software. RESULTS：A total of 12 literatures were included,involving 1390 patients. The cure rate [RR=1.91,95%CI（1.59,2.29）,P=0.005] and total effective rate [RR=1.19,95%CI（1.14,1.25）,P=0.85] of Xianling gubao capsule combined with routine therapy were better than routine therapy alone;there was no statistical significance in the incidence of ADR [RR=0.58,95%CI（0.18,1.90）,P=0.63]. CONCLUSIONS：XLGB is effective for KOA,and the incidence of ADR of it is similar to routine therapy. Due to low-quality of included studies,above conclusion need to be confirmed by strictly designed large-scale and high-quality RCTs.