噻托溴铵联合无创通气治疗COPDⅡ型呼吸衰竭68例疗效观察

The Observation of Tiotropium Bromide Combined with Noninvasive Ventilation with Bi-level Positive Airway Pressure Model in the 68 Patients with Type Ⅱ Respiratory Failure by COPD

目的探讨噻托溴铵联合无创通气治疗慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭的疗效。方法 68例慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭的患者,随机分为对照组和治疗组。两组均予氧疗、抗感染、祛痰、支气管扩张剂等常规治疗及无创通气治疗;治疗组在此基础上加用噻托溴铵粉吸入剂(思力华)治疗。比较两组治疗前后动脉血气变化、第1秒用力呼气量占预计值百分比(FEV1%)、呼吸困难评分(MMRC)。结果两组患者治疗后动脉血气、FEV1%、MMRC均较治疗前显著改善,组内及组间差异均有统计学意义(P<0.05)。结论噻托溴铵联合无创通气治疗可有效改善慢性阻塞性肺病合并Ⅱ型呼吸衰竭患者血气等,值得临床推广应用。

Objective To estimate the efficacy of tiotropium bromide combined with noninvasive ventilation with Bi-level positive airway pressure model in the patients with type Ⅱ respiratory failure by COPD. Methods Sixty-eight patients with type Ⅱ respiratory failure by COPD were randomly divided into two groups. The two groups were given oxygen therapy, anti-infection, eliminating phlegm, bronchodilators and noninvasive ventilation, except that the treatment group was given tiotropium bromide Powder for Inhalation.The arterial blood gas, FEV1%,MMRC. Results After treatment the arterial blood gas、FEV1% and MMRC were improved, but the treated group was better（P〈0.05）. Conclusion Tiotropium bromide combined with Noninvasive ventilation can improve the arterial blood gas,FEV1% and MMRC, This is a valuable method in treatment of the patient with type Ⅱrespiratory failure by COPD.