摘要
目的探讨卡介菌多糖核酸治疗肺结核合并糖尿病患者的疗效。方法 96例肺结核合并糖尿病患者分为两组,观察组48例,对照组48例,对照组采用常规降糖、抗痨治疗。观察组在常规治疗的基础上加用卡介菌多糖核酸治疗。观察痰结核杆菌3、6个月转阴率,病灶吸收情况,血清干扰素-γ(IFN-γ)的变化。结果观察组在治疗后3、6个月的痰菌转阴率分别为77.1%、91.7%;对照组分别为64.6%、77.1%;观察组痰菌转阴率均明显高于对照组(χ2=9.16,13.24,P<0.05)。治疗后对照组总有效率为77.1%,观察组总有效率为91.7%;观察组总有效率明显高于对照组(χ2=13.24,P<0.05)。治疗后两组患者血清IFN-γ均有明显升高(P<0.01),并且观察组升高更明显(P<0.05)。结论卡介菌多糖核酸可以增强肺结核合并糖尿病患者的免疫功能,加速疾病的愈合。
Objective To study the effectiveness of BCG polysaccharides nucleic acid on patients with type 2 diabetic plus tuberculosis. Methdos 96 patients with type 2 diabetic plus tuberculosis were randomly divided into two groups,the observation group(n=48 cases) and the control group(n=48 cases). The patients in the control group were treated through conventional hypoglycemic, anti-tuberculosis treatment.The patients in the observation group were treated through conventional treatment plus BCG polysaccharides nucleic acid. Mycobacterium tuberculosis sputum negative rate of 3,6 months, the lesions absorption, serum interferon-γ(IFN-γ) changes were observaed. Results Sputum negative rates first 3,6 months after treatment were 77.1%, 91.7% in the observation group and 64.6%, 77.1% in the control group. Sputum negative rate in the observation group were significantly higher(χ^2=9.16,13.24, P〈0.05). The total effective rates were 77.1% in the control group and 91.7% in the observation group.The total effective rate was significantly higher(χ^2=13.24, P〈0.05). The two groups after treatment were significantly elevated in patients with serum IFN-γ and compared with the control group after treatment, the observation group significantly evelated(P〈0.05).Conclusions BCG tuberculosis nucleic acid can enhance immune function in patients with diabetes, accelerate healing diseases.
出处
《中国医药指南》
2014年第25期52-53,共2页
Guide of China Medicine
关键词
肺结核
糖尿病
卡介菌多糖核酸
Tuberculosis
Diabete
BCG polysaccharides nucleic acid