hs-CRP和IL-6动态变化与脑动脉狭窄支架成形术后再狭窄的相关性研究

Study of relationship between levels of hs-CRP and IL-6 with restenosis after stent angioplasty in cerebral arterial stenosis

目的探讨血清超敏C反应蛋白(hs-CRP)和IL-6的动态变化与脑动脉狭窄支架成形术后再狭窄的相关性。方法回顾分析2011年3月至2013年3月在河南省南阳市中心医院行脑动脉狭窄支架成形术的患者65例,观察其术前、术后不同时间点hs-CRP和IL-6水平变化,并分析其与血管再狭窄的相关性。结果 (1)脑动脉狭窄程度与患者血清hs-CRP和IL-6水平呈正相关(P<0.05)。(2)术后各时间点患者hs-CRP和IL-6水平明显升高,并于术后12h达到最高值后逐渐下降,而且再狭窄患者手术7d后hs-CRP和IL-6水平均显著高于无再狭窄患者,差异均有统计学意义(P<0.05)。(3)术后6个月与术前比较,无再狭窄患者血清hs-CRP和IL-6水平下降明显,但再狭窄患者的差异无统计学意义(P>0.05);有无再狭窄患者之间△hs-CRP和△IL-6比较差异均有统计学意义(P<0.05)。结论血清hs-CRP和IL-6可能在支架成形术后脑动脉再狭窄的过程中起着重要作用,监测血清hs-CRP和IL-6的动态变化对评估血管再狭窄具有一定价值。

Objective To investigate the relationship between the dynamic changes of hs-CRP and IL-6 with restenosis after stent angioplasty in cerebral arterial stenosis .Methods 65 patients with cerebral artery stenosis stent angioplasty in Nanyang Mu-nicipal Central Hospital from March 2011 to March 2013 were retrospectively analyzed .The changes of hs-CRP and IL-6 levels be-fore operation and at different postoperative time points were observed and their correlation with vascular restenosis was anlyzed . Results （1）The cerebral artery stenosis degree and serum hs-CRP and IL-6 levels were positively correlated（P〈0 .05） .（2）Com-paring the hs-CRP and IL-6 levels at different time points showed that the postoperative hs-CRP and IL-6 levels were significantly increased ,reached the highest at postoperative 12 h and then gradually declined .The hs-CRP and IL-6 levels on postoperative 7 d in the patients with restenosis were significantly higher than those in the patients without restenosis （P〈0 .05） .（3）The hs-CRP and IL-6 levels at postoperative 6 months in the patients without restenosis were significantly decreased compared with before opera-tion ,but which in the patients with restenosis had no statistically significant differences （P〉0 .05）;△hs-CRP and △IL-6 had sta-tistically significant differences between the patients with restenosis and the patients without restenosis （P〈0 .05） .Conclusion hs-CRP and IL-6 may play an important role in the process of restenosis after stent angioplasty in cerebral arterial stenosis .Monitoring the dynamic changes of hs-CRP and IL-6 has certain value for evaluating vascular restenosis .