弥散登记在磁共振弥散张量成像中的应用价值研究

Application value of diffusion registration in diffusion tensor imaging

目的通过对比磁共振弥散张量成像(DTI)数据进行两种处理后获得的ADC值、eADC值、FA值和可视神经纤维长度,研究弥散登记在磁共振DTI中的应用价值。方法对20例进行磁共振DTI者的资料进行回顾性分析,分别应用原始数据直接处理获得ADC值、eADC值和FA值,施加弥散登记处理后再进行ADC值、eADC值和FA值测量,同时对两种不同处理方式进行纤维示踪成像,分别比较每例研究者的ADC值、eADC值和FA值在施加弥散登记前后变化,同时比较在施加弥散登记前后纤维示踪图像上相同兴趣区测量所得纤维束长度差异。结果健康对照组施加弥散登记处理前后获得ADC值、eADC值差异无统计学意义(P=0.695 3,P=0.632 1),FA值差异有统计学意义(P=0.032 1);研究组施加弥散登记处理前后获得ADC值、eADC值差异无明显统计学意义(P=0.203 9,P=0.075 4),FA值差异有统计学意义(P=0.011 4),施加弥散登记后可视纤维束变长。结论弥散登记处理可获得较好质量的ADC图、eADC图、FA图和纤维示踪图,并获得更为可靠的ADC值、eADC值和FA值。可见纤维束长度变长,在磁共振DTI中有较大应用价值。

Objective To evaluate the value of diffusion registration in diffusion tensor imaging （DTI） through comparing the diffusion tensor data to conduct the two kinds of post-processing methods for obtaining the ADC ,eADC and FA values and the vis-ual neural fiber length .Methods 20 cases of DTI data were analyzed retrospectively .The original data were adopted to directly process for obtaining the ADC ,eADC and FA values respectively ,after exerting diffusion registration the ADC ,eADC and FA val-ues were measured again ,at the same time the two different processing modes were performed the fiber trace imaging ,.The changes of ADC ,eADC and FA values in each case were compared before and after exerting the diffusion registration ,and at the same time the differences of fiber length in the same interest area in the fiber trace image were compared before and after exerting the diffusion registration .Results The difference of the ADC and eADC values obtained before and after exerting the diffusion registration in the normal group showed no statistical significance （P=0 .695 3 ,P=0 .632 1） and the FA value difference between before and after ex-erting the diffusion registration had statistical significance （P=0 .032 1）;the difference of the ADC and eADC values obtained be-fore and after exerting the diffusion registration in the clinical patients group had no statistical significance （ P= 0 .203 9 ,P=0 .075 4） ,the FA value difference had statistical significance （P=0 .011 4） ,the visual neural fiber length was elongated after exer-ting the diffusion registration .Conclusion The diffusion registration processing can obtain better quality of ADC ,eADC ,FA images and the fiber trace image ,more reliable ADC ,eADC and FA values ,the visual fiber length is elongated ,which has large application value in MR DTI .