重庆市9328例宫颈上皮内病变HPV感染型别及危险因素调查

Survey on types and risk factors of HPV infection among 9 328 persons with cervical intraepithelial neoplasia in Chongqing

目的了解重庆市宫颈上皮内病变中高危型人乳头瘤病毒(HPV)感染型别和危险因素,为宫颈癌的防治提供依据。方法选取2012年6月至2013年12月于重庆市多家医院就诊并做宫颈癌液基细胞学筛查的患者做HPV分型成功9 328例,统计分析不同等级宫颈上皮内病变中HPV感染主要型别,确定危险因素。结果 HPV16是重庆地区最常见的感染型别,其次为HPV52、58、33、18,性伴侣多、第一次性生活年龄小、人工流产等因素是HPV感染的危险因素。结论重庆市不同宫颈病变人群中HPV感染主要以单一型别、高危型感染为主,宫颈细胞学病变级别越高HPV感染率越高。对于HPV感染的危险因素应加强宣教,有助于预防宫颈癌的发生。

Objective To understand the types and risk factors of human papillomavirus （HPV ） infection among the patients with cervical intraepithelial neoplasia in Chongqing to provide a scientific basis for prevention and treatment of cervical cancer . Methods The patients with TCT screening in many hospital of Chongqing from June 2012 to December 2013 were selected and performed the HPV typing ,9 328 cases succeeded in HPV typing .The main types of HPV infection in different grades of cervical intraepithelial neoplasia were statistically analyzed for determining the risk factors .Results HPV16 was the most common infection type among patients with cervical intraepithelial neoplasia in Chongqing area ,followed by HPV52 ,58 ,33 ,18 .Some factors such as multiple sex partners ,young female with sexual debut and induced abortion were the risk factors of HPV infection .Conclusion Single and high-risk type is the main feature of HPV infection among the patients with cervical intraepithelial neoplasia in Chongqing .The infection rate is higher with the higher grade of cervical intraepithelial neoplasia .Publicity and education for risk factors of HPV infection should be strengthened ,which will help to prevent the occurrence of cervical cancer .