支气管哮喘患者诱导痰和血清C反应蛋白临床意义及相关性的研究

The Clinical Significance and Correlation Study on Patients with Bronchial Asthma Induced Sputum and Serum C-reactive Protein

目的:观察血清及诱导痰C反应蛋白(CRP)是否可以作为支气管哮喘急性发作期病情判断的敏感指标。方法:检测本科收治的30例支气管哮喘急性发作期患者(治疗组)治疗前及治疗后同期血清和诱导痰中CRP的浓度,同时检测30例健康体检者(对照组)的血清CRP浓度,并进行比较分析。结果:治疗组治疗前的血清CRP、诱导痰CRP均明显高于治疗后及对照组,且治疗后的血清CRP明显高于对照组,差异均有统计学意义(P<0.05)。治疗组治疗前、后的血CRP和诱导痰CRP均存在显著正相关性(r=0.907、0.743,P<0.01)。结论:血清及诱导痰CRP可作为一种动态监测气道炎症以及评估支气管哮喘患者疾病严重程度的实用及无创的检测方法。

Objective：To observe the serum and induced sputum C-reactive protein（CRP）whether can be used as a sensitive index of acute attack of bronchus asthma severity.Method：The concentration of CRP in the serum and induced sputum of 30 bronchial asthma patients with acute phase（the treatment group）before and after treatment in the same period were detected,and the concentration of CRP in normal people（the control group）were detected,the results were compared and analyzed.Result：The CRP of the serum and induced sputum in the treatment group before treatment were significantly higher than after treatment and the control group,and the CRP of the serum after treatment was significantly higher than the control group,the differences were statistically significant（P〈0.05）.The CRP of the serum and induced sputum in the treatment group before treatment and after treatment were significant positive correlation （r=0.907,0.743,P〈0.01）.Conclusion：The CRP of serum and induced sputum can be used as a kind of dynamic monitoring of airway inflammation and a practical and noninvasive detection method in evaluating severity in patients with bronchial asthma disease.