乌司他丁治疗新生儿脓毒症的疗效观察

Clinical Effect Observation of Ulinastatin on Neonatal Sepsis

目的:观察乌司他丁治疗新生儿脓毒症的临床效果。方法:将48例新生儿脓毒症患儿按随机数字表法分为治疗组(n=25)和对照组(n=23)。对照组给予常规治疗,治疗组在常规治疗的基础上加用乌司他丁,比较两组治疗前后的体温(T)、呼吸(RR)、心率(HR)、白细胞计数(WBC)、肝肾功能等指标的变化,同时比较两组治疗有效率及病死率的变化。结果:两组治疗后T、R、HR、WBC均较治疗前明显改善(P<0.05);两组的血浆CRP、PCT、ALT、TBIL、DBIL、Cr、BUN、LDH、CK-MB、PT、APTT、D-D、IL-6、TNF-α、NSE较前均明显下降(P<0.05),FIB、IL-10较前明显升高(P<0.05),且乌司他丁组除Cr、BUN外,上述其余指标较对照组改变更明显(P<0.05)。两组的有效率比较差异有统计学意义(P<0.05);两组的病死率比较差异无统计学意义(P>0.05)。结论:乌司他丁治疗新生儿脓毒症具有良好的临床疗效,值得临床推广应用。

Objective：To observe the clinical effect of ulinastatin in treating neonatal sepsis.Method：48 cases of neonatal sepsis were randomly divided into the treatment group（n=25）and the control group（n=23）. The control group just received conventional therapy,while the treatment group added ulinastatin. The indexs of temperature（T）,respiration rate（RR）,heart rate（HR）,white blood cell count（WBC）,liver and kidney function,and so on of the two groups were compared,and treatment efficiency and case-fatality rate between pre-treatment and post-treatment were compared too. Result：The two groups obtained improvement in T,R,HR,WBC than pre-treatment（P〈0.05）;and the CRP,PCT, ALT,TBIL,DBIL,Cr,BUN,LDH,CK-MB,PT,APTT,D-D,IL-6,TNF-α,NSE levels decreased significantly in plasma in both groups after treatment（P〈0.05）;and the FIB,IL-10 levels increased significantly in both groups （P〈0.05）. The above indicators except Cr,BUN in the treatment group changed more significantly than the control group （P〈0.05）. The difference of efficient between the two groups was statistically significant（P〈0.05）;the case fatality rate of the two groups had no statistical significance（P〉0.05）.Conclusion：Ulinastatin is effective in treating of neonatal sepsis patients and it deserve to be applied universally.