PET凋亡细胞显像探针的研究进展

Advances in radiotracer for PET imaging of apoptosis

细胞凋亡是生命体的一种基本生理机制。活体检测肿瘤组织的凋亡细胞将来可能应用于临床实践,尤其是对肿瘤治疗和预后的预测,对指导肿瘤个体化治疗具有重要的意义。PET作为分子影像显像手段,在凋亡显像研究中具有很大优势。基于凋亡显像的重要性,许多有潜力的PET探针被开发出来,包括正电子核素标记的膜联蛋白Annexin-V,靛红衍生物类Caspase-3抑制剂、疏水性阳离子和Apo-sense化合物,上述探针针对凋亡过程中的不同靶点,能够不同程度地反映出活体组织细胞凋亡状态。

Apoptosis is a fundamental biologic process. Molecular imaging of apoptosis in vivo may have important implications for clinical practice, especially for treatment and prognosis of malignancies. PET, as a radionuclide imaging method, has an advantage in functional molecular imaging, which plays an important role in apoptosis imaging studies of tumor. In recent years, many PET probes based on the importance of apoptosis imaging are being developed, including positron radionuclide labeled Annexin-V, Caspase-3 inhibitor, Hydrophobic positive ion and the structures targeting various steps of the apoptotic cascade mentioned above can reflect the apoptotic status of living tissue cells.