清窦灵合剂鼻腔冲洗治疗慢性鼻-鼻窦炎鼻内镜术后临床研究

Nasal Endoscope Postoperative Clinical Research on Chronic Rhinosinusitis Treated by Nasal Irrigation with QingDouLing Mixture

目的观察清窦灵合剂鼻腔冲洗对慢性鼻-鼻窦炎鼻内镜术后患者的临床疗效。方法 60例慢性鼻-鼻窦炎鼻内镜术后患者随机分为治疗组和对照组各30例,对照组采用0.9%的氯化钠注射液鼻腔冲洗,治疗组采用0.9%的氯化钠注射液中加入清窦灵合剂鼻腔冲洗,测定2组术前及术后1个月、3个月、6个月鼻黏膜纤毛传输速率(MTR);随访6个月以上,观察2组临床疗效。结果术后1个月及术后3个月治疗组MTR比对照组增快,2组差异有显著性意义(P<0.05);术后6个月2组MTR差异无显著性意义(P>0.05);术后3个月、6个月2组疗效比较,治疗组病情完全控制率、总有效率均明显高于对照组,差异有显著性意义(P<0.05)。结论清窦灵合剂鼻腔冲洗在控制鼻腔炎症、减少分泌物,改善患者的临床症状,减轻术腔水肿,防止肉芽及囊泡形成,促进术腔上皮化,促进鼻黏膜纤毛功能早期恢复等方面均有较好疗效。

OBJECTIVE To observe the clinical efficacy on the chronic rhinosinusitis patients treated by nasal irrigation with QingDouLing Mixture.METHODS 60 cases of chronic rhinosinusitis and nasal endoscopic surgery were randomly divided into treatment group and control group with 30 cases in each group.The control group had nasal irrigation by using 0.9% sodium chloride injection,treatment group had nasal irrigation by using 0.9% sodium chloride injection with QingDouLing Mixture added.Nasal mucociliary transport rates （MTR） in both groups were measured before and 1 month,3 months and 6 months after operation respectively.Follow-up visiting was kept for over 6 months to observe the clinical curative effect of the two groups.RESULTS MTR in treatment group of postoperation for 1 month and 3 months was faster than that of the control group.There was significant difference between two groups （P〈0.05）.There was no significant difference on MTR between the two groups when 6 months （P〉0.05）.Compared 3 months with 6 months,after the operation the overall control rate and total effective rate in treatment group were significantly higher than that of the control group,with significant difference （P〈 0.05）.CONCLUSION QingDouLing Mixture for nasal irrigation has good curative effect on many aspects,such as controlling the inflammation of the nasal cavity,reducing secretion,improving clinical symptoms,reducing the operation cavity edema to prevent granulation and vesicle formation,promoting the operation cavity epithelization,and promoting early recovery of nasal mucociliary function,etc.