当归四逆汤防治奥沙利铂周围神经毒性的临床观察

Clinical Observation on Danggui Sini Decoction in Preventing and Treating Oxaliplatin Neurotoxicity

目的观察当归四逆汤防治奥沙利铂神经毒性的临床效果。方法将48例符合纳入标准的患者随机分为治疗组和对照组,每组各24例。2组均给予含奥沙利铂的化疗方案,治疗组同时加用当归四逆汤,各组均以21d为1个疗程,共治疗4个疗程,观察临床中医证候疗效及治疗后神经毒性分级情况。结果治疗后治疗组、对照组临床中医证候总有效率分别为70.8%、37.5%(P<0.05);治疗后2组神经毒性总发生率分别为33.3%、62.5%(P<0.05)。结论当归四逆汤对奥沙利铂导致的神经毒性有明显的防治作用。

OBJECTIVE To observe the efficacy of Danggui Sini Decoction in preventing and treating oxaliplatin neurotoxicity.METHODS 48 patients in accordance with criteria were randomly divided into treatment group and control group with 24 cases in each.All the patients had been treated with chemotherapy which contained oxaliplatin.Furthermore,treatment group were simultaneously given Danggui Sini Decoction.Each group was treated for four courses with 21 days in each course.The neurotoxicity classification and clinical therapeutic effect of Chinese Medicine were observed after treatment.RESULTS The total effective rate of TCM syndromes after therapy was 70.8% and 37.5% respectively in treatment group and the control group （P〈0.05）.The total incidence of neurotoxicity after therapy of the treatment group and the control group（P〈0.05）.CONCLUSION Danggui Sini Decoction is effective on preventing and treating oxaliplatin neurotoxicity.