疏血通注射液对原发性高血压患者RAAS活性的影响

Effect of Shuxuetong Injection on Renin angiotensin aldosterone System in Essential Hypertension

目的观察疏血通注射液对原发性高血压患者肾素血管紧张素醛固酮系统(RAAS)活性的影响。方法将入选的原发性高血压患者随机分为治疗组和对照组,观察两组治疗前后血压、血浆肾素(PRA)、血管紧张素Ⅱ(AngⅡ)、醛固酮(ALD)水平及血脂、血流液变学指标的变化。结果治疗后两组患者血浆AngⅡ、ALD均较治疗前有所降低,治疗组降低更为明显(P<0.05),两组患者血浆肾素水平较治疗前升高,但差异无统计学意义(P>0.05)。治疗组治疗后血压、血脂、血液流变学指标明显改善,与对照组相比差异有统计学意义(P<0.05或P<0.01)。结论疏血通注射液对原发性高血压患者RAAS活性有明显改善,可降低血浆AngⅡ、ALD的含量,改善血液流变学特性,有效降低血压。

O bjective To observe the effect of Shuxuetong injection on renin ang io tensin aldosterone system in patients w ith essential hypertension.M ethods O ne hundred and tw enty patients w ith essential hypertension w ere random ly divided tw o groups . The curative effect of tw o groups w as assessed before trea tm ent and after treatm ent.At the sam e tim e blood lipids ,hem orheo log ical param eters ,PRA ,AngⅡ and ALD w ere observed.Results After treatm entw ith Shuxuetong injection , the level of serum PRA w as increased but there w as no t a significant difference（ P〉0.05） .The level of serum Ang Ⅱ and ALD w as descended and there w as a significant difference com pard w ith the contro lgroup（ P〈0.05） .The lipids and hem orheo log icalparam eters in the treating group w ere m proved obviously ,and the difference w as significant com pared w ith the contro lgroup（ P〈0.05） .Conclusion Shuxuetong injection could im prove rennin ang io tension aldos terone system fo r essential hypertension , raise the levelof PRA , lower the content ofAngⅡand Ald, lower blood pressure effectively.