同型半胱氨酸及血管内皮功能检测在脑梗死中的应用

Clinical application of homocysteine and vascular endothelial function determinations in cerebral infarction

目的观察脑梗死患者血清同型半胱氨酸(Hcy)、血管内皮功能指标[内皮素(ET-1)、一氧化氮(NO)、血管内皮生长因子(VEGF)]的变化,探讨其与脑梗死的关系及临床应用价值。方法分别检测90例脑梗死患者(脑梗死组)及80名体检健康者(正常对照组)血清Hcy、NO、ET-1及VEGF水平,计算异常检出率并进行分析比较。结果与正常对照组比较,脑梗死组血清Hcy、ET-1、VEGF水平明显升高(P<0.05),NO水平明显降低(P<0.05)。脑梗死组血清Hcy、NO、ET-1及VEGF的异常检出率明显高于正常对照组(P<0.05)。结论Hcy及血管内皮功能指标与脑梗死有一定的关系。

Objective To observe serum homocysteine （Hey） and vascular endothelial function parameters such as endothelin-1 （ET-1）, nitric oxide（NO） and vascular endothelial growth factor（VEGF） in cerebral infarction patients, and to investigate the relationship with cerebral infarction and the clinical application significance. Methods The levels of serum Hcy, NO, ET-1 and VEGF were determined in 90 patients with cerebral infarction （cerebral infarction group） and 80 healthy subjects （healthy control group）. The abnormal determination rate was calculated, and the results were analyzed comparatively. Results The levels of serum Hcy, ET-1 and VEGF increased significantly in cerebral infarction group compared with those in healthy control group （ P 〈 0.05 ） , but NO level decreased significantly （ P 〈 0.05）. The abnormal determination rates of serum Hcy, NO, ET-1 and VEGF in cerebral infarction group were higher than those in healthy control group （ P 〈 0.05 ）. Conclusions Hcy and vascular endothelial function parameters are related to cerebral infarction.