血清淀粉样蛋白A与C反应蛋白联合检测的临床应用价值

Clinical application significance of serum amyloid A and C-reactive protein combined determination

目的评估血清淀粉样蛋白A(SAA)与C反应的蛋白(CRP)联合检测的临床应用价值。方法采用胶体金法和免疫散射比浊法对82例感染性疾病组(包括15例肺炎、23例急性支气管炎、17例急性阑尾炎、16例急性胆囊炎、11例胰腺炎)患者及92名正常对照组的血清SAA和CRP水平进行检测,并比较两者间的浓度中位数及各疾病组的阳性检出率。结果感染性疾病组患者血清SAA与CRP浓度中位数水平分别为149.50 mg/L、34.20 mg/L,明显高于正常对照组分别为4.60 mg/L、3.82 mg/L,差异有统计学意义(P<0.05);感染性疾病组血清SAA,与CRP阳性检出率分别为87.80%与79.26%。结论感染性疾病时,SAA与CRP水平变化趋势基本一致,且较CRP更为敏感。SAA与CRP都可作为一种监测炎症的有价值的标志物[1],SAA与CRP联合检测可以更有效的提高感染性疾病的检出率,为临床医生提供更敏感的诊断依据。

Objective To evaluate the clinical application significance of the combined determination of serum amyloid A （SAA） and C-reactive protein （CRP）. Methods The levels of serum SAA and CRP in 82 inflammatory disease patients （15 cases of pneumonia, 23 cases of acute bronchitis, 17 cases of acute appendicitis, 16 cases of acute choleeystitis and 11 cases of panereatitis ） and 92 healthy controls were determined by colloidal gold method and imnmnoturbidimetry, respectively. Their concentration median and positive determination rate were analyzed comparatively between the 2 groups. Results The serum SAA and CRP medians in inflammatory disease group were 149.50 mg/L and 34. 20 mg/L, respectively, which were obviously higher than those in healthy control group （4.60 mg/L and 3.82 mg/L）. There was a statistical significance between the 2 groups （P 〈 0.05）. The positive determination rates of serum SAA and CRP in inflammatory disease group were 87.80% and 79.26% , respectively. Conclusions SAA has the same trend with CRP when inflammatory disease happens, and shows a more sensitive performance than CRP. SAA and CRP can be used as meaningful markers for monitoring inflammation. The combined determination of SAA and CRP could improve the determination rate of inflammatory disease, which provides a more sensitive reference for diagnosis.