糖尿病视网膜病变患者血清胎球蛋白A水平的变化及其与CRP的相关性

The changes of serum alpha2-Heremans-Schmid glycoprotein level and its correlation with CRP in patients with diabetic retinopathy

目的探讨糖尿病视网膜病变(DR)患者血清胎球蛋白A(AHSG)水平的变化及其与C反应蛋白(CRP)的相关性。方法选取2型糖尿病(T2DM)患者115例,分为糖尿病无视网膜病变(NDR)组46例、非增生性糖尿病视网膜病变(NPDR)组37例、增生性糖尿病视网膜病变(PDR)组32例;另选取正常对照组40名。采用酶联免疫吸附试验(ELISA)测定血清AHSG与CRP水平。结果 NDR组、NPDR组及PDR组血清AHSG及CRP水平均高于正常对照组,组间比较及组内两两比较差异均有统计学意义(P<0.05,P<0.01)。T2DM患者的血清AHSG水平与CRP呈正相关(r=0.239,P<0.05)。结论 AHSG水平升高与DR的病情严重程度有关,其可能通过促炎性效应参与DR的发生、发展。

Objective To investigate the changes of serum alpha2-Heremans-Schmid glycoprotein (AHSG)level and its correlation with C-reactive protein (CRP)in patients with diabetic retinopathy (DR).Methods Serum levels of AHSG and CRP were determined by enzyme-linked immunosorbent assay (ELISA)in 1 1 5 type 2 diabetes mellitus (T2DM)patients,and the 1 1 5 T2DMpatients were classified into 3 groups,46 patients with non-diabetic retinopathy (NDR),37 patients with non-proliferative diabetic retinopathy (NPDR)and 32 patients with proliferative diabetic retinopathy (PDR).A total of 40 healthy controls were enrolled.Results The serum levels of AHSG and CRP in NDR group,NPDR group and PDR group were higher than that in healthy control group,and there was statistical significance among the groups(P <0.05,P <0.01 ).Serum AHSG level in T2DMpatients was positively correlated with CRP (r =0.239,P <0.05).Conclusions The increasing of AHSG level is correlated with the severity of DR,and it may be involved in the development and pathogenesis of DR by proinflammatory effects.