可溶性血管细胞黏附分子1、妊娠血浆相关蛋白-A和白细胞介素6在妊娠高血压综合征中的作用

Levels and pathophysiological roles of soluble vascular cell adhesion molecule-l,pregnancy associated plasmaprotein A and interleukin-6 in pregnancy-induced hypertension

目的探讨可溶性血管黏附分子1(soluble vascular cell adhesion molecule-l,sVCAM-1)、妊娠血浆相关蛋白-A(pregnancy associated plasmaprotein A,PAPP-A)和白细胞介素6(interleukin-6,IL-6)在妊娠高血压综合征(妊高征)发病中的作用。方法选取92例妊娠期高血压疾病孕妇(其中妊娠期高血压50例,子痫前期30例,子痫12例)和80例健康孕妇为对照组,检测其sVCAM-1、PAPP-A和IL-6水平。结果子痫前期、子痫患者血清sVCAM-1、PAPP-A和IL-6水平显著高于对照组(P<0.01),子痫前期、子痫患者sVCAM-1和PAPP-A有显著正相关性(r=0.85,P<0.05),IL-6和sVCAM-1呈正相关(r=0.64,P<0.05)。结论 sVCAM-1、PAPP-A和IL-6与妊娠期高血压疾病发作进展存在明显关联性,可推广性应用于实际临床工作,提高子痫早期诊疗率,降低孕产妇及围生儿病死率。

Objective To investigate the roles of soluble vascular cell adhesion molecule-l（ sVCAM-1） , pregnancy associated plasmaprotein A（PAPP-A） and interleukin-6（IL-6） in pregnancy-induced hypertension.Methods Ninety-two pregnant woman diag-nosed as having pregnancy-induced hypertension were recruited and divided into gestational hypertension group （50 cases）, preeclamp-sia group（30 cases）and eclampsia group（12 cases）.Eighty healthy pregnant women were set as controls .sVCAM-1、PAPP-A were measured by chemiluminescence and IL-6 was measured by radioimmunoassay .Results The levels of sVCAM-1, PAPP-A and IL-6 in preeclampsia group and eclampsia group were significantly higher than those in control group （P〈0.01）.The levels of sVCAM-1 and PAPP-A had significant correlation in groups of preeclampsia and eclampsia （r=0.85, P〈0.05）, and the levels of IL-6 and sVCAM-1 had positive correlation in groups of preeclampsia and eclampsia （r=0.64, P〈0.05）.Conclusions SVCAM 1, PAPP-A and IL-6 have obvious ralationship with gestational hypertension .They can be applied in the clinical generalization , increase the rate of early diagnosis and treatment of eclampsia and reduce maternal and perinatal mortality .