基础FSH水平对不同年龄患者行供精人工授精结局的影响

Effect of basal follicle-stimulating hormone levels on the outcomes of artificial insemination with donor's semen in infertile patients of different ages

目的：探讨年龄、血基础卵泡刺激素（bFSH）水平对不孕妇女行供精人工授精（AID）结局的影响。方法：回顾性分析郑州大学第一附属医院生殖中心2008年1月-2013年12月成功接受供精人工授精治疗的不孕妇女的年龄、bFSH水平与临床妊娠率、流产率的关系。结果：①3247个AID周期中，〈35岁组和≥35岁组诱导排卵的妊娠率分别为28．76％，16．04％；自然周期的妊娠率分别为28．88％，16．93％，不同年龄诱导排卵妊娠率及自然周期妊娠率比较，差异有统计学意义（P〈0．05）。②〈35岁患者中，bFSH≤10IU／L组诱导排卵和自然周期的妊娠率均高于bFSH〉10IU／L组（P〈0．05），流产率对比均无统计学差异（P〉0．05）。③≥35岁患者中，bFSH≤10IU／L组与bFSH〉10IU／L组诱导排卵或自然周期的妊娠率、流产率均无统计学差异（P〉0．05）。结论：年龄是影响AID助孕结局的重要因素之一；基础FSH水平对年龄〈35岁患者妊娠结局有一定预测作用；诱导排卵并未明显增加AID妊娠率；AID助孕技术并未增加流产风险。

Objective： To explore the effects of age and basal follicle -stimulating hormone （bFSH） levels on outcomes of artificial insemination with donor＇s semen （AID） in infertile patients. Methods： The relationships between age, bFSH levels and clinical preg- nancy rate, miscarriage rate in infertile women treated by AID successfully from January 2008 to December 2013 in the hospital were analyzed retrospectively. Results： In 3 247 AID cycles, the pregnancy rates of induced ovulation in 〈 35 - year - old group and ≥ 35 - year - old group were 28.76% and 16. 04%, respectively; the pregnancy rates of natural cycles in 〈 35 - year - old group and ≥ 35 - year - old group were 28. 88% and 16.93%, respectively; there were statistically significant differences in the pregnancy rates of induced ovulation and natural cycles between the two age groups （P 〈 0. 05） . Among the infertile women under 35 years old, the pregnancy rates of induced ovulation and natural cycles in infertile women with bFSH ≤ 10 IU/L were statistically significantly higher than those in infertile women with bFSH 〉 10 IU/L （P 〈 0.05）, there was no statistically significant difference in abortion rate （P 〉 0. 05 ） . Conclusion： Age is one important factor affecting the outcomes of AID. bFSH level plays a certain predictive role for pregnancy outcomes of infertile women under 35 years old. Induced ovulation does not increase AID pregnancy rate significantly; AID does not increase the risk of abortion.