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阿屈非尼的合成

Synthesis of Adrafinil
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摘要 二苯甲酮经还原得二苯甲醇,与巯基乙酸缩合得2-(二苯甲硫基)乙酸,再经双氧水氧化、甲醇酯化和盐酸羟胺酰胺化反应得到阿屈非尼,总收率约76%。 Adrafinil was synthesized from benzophenone by reduction with KBH4 to give diphenylcabinol, which was subjected to condensation with thioglycolic acid, oxidation by H2O2, esterification with CH3OH and amidation with hydroxylamine hydrochloride with an overall yield of about 76 %.
作者 徐杰 彭学东 张梅 唐汝培
机构地区 江南大学医药学院 江苏斯威森生物医药工程研究中心有限公司
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2014年第10期910-912,共3页 Chinese Journal of Pharmaceuticals
关键词 阿屈非尼 抗抑郁药 合成 adrafinil antimelancholic drug synthesis
分类号 R971.7 [医药卫生—药品]
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参考文献6

  • 1Siwak CT, Callahan H, Milgram NW. Adrafinil: effects on behavior and cognition in aged canines [ J] . Prog Neuropsychopharmacol Biol Psychiatry, 2000, 24( 5) :709-726.
  • 2Louis L. New benzhydrysulphinyl derivatives: US, 4066686 [P]. 1978-01-03.
  • 3Guy A, Valerie de L, Sylviane M. Preparation of polyamine(s), substd. on terminal nitrogen atoms: FR, 2714052[P]. 1993-12-22.
  • 4陆江海,王杉,邓静,张亦农,吴侔天,张长久.阿屈非尼的合成和NMR研究[J].中国新药杂志,2005,14(5):583-584. 被引量：1
  • 5Prisinzano T, Podobinski J, Tidgewell K, et al. Synthesis and determination of the absolute configuration of the enantiomers of modafinil [J]. Tetrahedron: Asymmetry, 2004, 15(8):1053-1058.
  • 6张珍明,王丽萍,李树安,赵红博,齐家娟,邵栋.改进Zagoumenny还原法制备二苯甲醇[J].兰州理工大学学报,2013,39(1):54-57. 被引量：4

二级参考文献14

  • 1Siwak CT, Callahan H, Milgram NW Adrafinil: effects on behavior and cognition in aged canines [.1 ]. Prog Neuropsychopharmacol Biol Psychiatry ,2000,24(5) :709 - 726.
  • 2Lafon L, Laboratoire L, Lafon SA. Acetamide derivatives[ P]. US,4177290. 1979 - 12 - 04.
  • 3Elena Carceller, Manuel Merlos, Marta Giral. Synthesis and structure-activity relationships of 1-Acyl-4-((2-methyl-3-pyridyl) cyanomethyl)piperazines as PAF Antagonists[J]. J Med Chem,1993,36 : 2984 - 2997.
  • 4LAFON L. New benzhydrysulphinyl derivatives [P. US, 4066686. 1978-01-03.
  • 5HUYSER E S, BREDEWF C J. Induced decompositions of ditbutyl peroxide in primary and secondary alcohols [J]. Jour- nal of the American Chemical Society, 1964, 86 ( 12 ) : 2401- 2405.
  • 6YAMATAKA H, MIYANO N, HANAFUSA T. Comparative mechanistic study of the reactions of benzophenone with n-bu- tylmagnesium bromide and n-butyllithium [-J. Journal of Or- ganic Chemistry, 1991,56 (7) : 2573-2575.
  • 7GOSSER L W. Hydrogenation of a diarylketone to a diaryl- methanol [-P-I. US,4302435. 1981-11-24.
  • 8BAWANE S P,SAWANT S 13. Kinetics of liquid-phase catalyt- ic hydrogenation of benzphenone to benzhydrol EJ. Organic Process Research Development, 2003,7 (5) - 769-773.
  • 9COHEN S G, SHERMAN W V. Inhibition and quenching of the light-induced reductions of benzophenone to benzpinacol and to benzhydrol [-J. The Journal of the American Chemical Society, 1963,85(11) 1642-1647.
  • 10包锡康,包泉兴,吴达俊.有机人名反应集[M].北京:化学工业出版社,1983:505.

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中国医药工业杂志
2014年 第10期

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