摘要
工业结晶分为间歇和连续两种操作方式。相较于间歇结晶,连续结晶具有设备占地面积小、生产效率高、产品质量可控性高等优点。本文研究蛋氨酸的连续结晶过程,结果表明,与间歇结晶产品相比,蛋氨酸连续结晶产品粒度大且分布均匀,聚结现象明显改善;同时测定了蛋氨酸连续结晶动力学参数,为产业化及结晶器设计提供支持。
Crystallization can be carried out in batch or continuous process. The continuous crystallization process has the advantages of small equipment size, improved process efficiency and crystal characteristics easy to control. Continuous crystallization of methionine was studied in this paper. The results indicated that compared with the products of batch crystallization, continuous crystallization resulted in bigger crystal size, narrowsize distribution, significantly reduced agglomeration. Dynamics of continuous crystallization of methionine was determined as to provide some references for the scale-up and crystallizer design.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2014年第10期973-977,共5页
Chinese Journal of Pharmaceuticals
关键词
蛋氨酸
连续结晶
粒度分布
动力学
methionine
continuous crystallization
size distribution
dynamics
