高血压患者同型半胱氨酸及炎症因子水平与颈动脉斑块的相关性分析

Relationship analysis between hemocysteine,inflammation factor and carotid plaques in 80 hyper-tensive patients

目的：探讨高血压患者同型半胱氨酸（Hcy）及超敏 C-反应蛋白（hs-CRP）水平与颈动脉斑块的相关性。方法选取2012年8月至2013年8月在湛江中心人民医院心内科治疗的80例高血压病患者为研究组，另外选择同期在我院体检中心体检的80例健康者为对照组。通过比较两组 Hcy 及 hs-CRP 值；同时分别检测高血压病患者中 Hcy 及 hs-CRP 值与颈动脉斑块轻、中、重度狭窄的关系。结果①研究组 Hcy 及 hs-CRP 与对照组比较差异有统计学意义（P ﹤0.01）。②高血压病患者中颈动脉斑块狭窄程度与其 Hcy 及 hs-CRP 呈正相关性，差异有统计学意义（P ﹤0.01）。结论高血压病患者应通过检测 Hcy 及 hs-CRP 两项指标筛选出高危人群进行早期防治，能有效减少脑梗死的发病率。

Objective To investigate the relationship between homocysteine（HCY）together with high sensitive c-reactive protein（hs-CRP）levels and carotid plaques in hypertensive patients. Methods Eighty hypertensive patients hospitalized in our hospital’s heart general medicine from August 2012 to Au-gust 2013 were taken as the study group. Another 80 health people in our hospital’s physical examination center at the same period were selected as the control group. The levels of HCY and hs-CRP were com-pared,at the same time the rectionship in hypertensive patients beween HCY,hs-CRP and light,medium and severe stenosis of carotid was detected. Results The levels of HCY and hs-CRP in study group were different from those in control group（P ﹤0. 01）. In the hypertensive patients,the extent of carotid plaques stenosis had positive correlation with HCY and hs-CRP levels（P ﹤0. 01）. Conclusions The levels of HCY and hs-CRP should be detected in hypertensive patients to screen the high risk patients. These patients can be prevented and treated early. This way can reduce the incidence of cerebral infarction effectively.