超小金纳米团簇作为CT对比剂的研究

Study on ultra-small gold nanoclusters as X-rays computed tomography contrast agent

采用X-射线断层扫描(Computed tomography,CT)技术测量肿瘤部位、肝、脾、肾、膀胱的CT值和不同时间点的二维、三维影像来评价谷胱甘肽(Glutathione,GSH)保护的超小金纳米团簇作为对比剂的可能性,并验证它的高效肿瘤摄取和清除作用。CT结果表明,肿瘤部位的加强对比作用随时间的增加而增加,加强的影像直至6 h仍未减弱,因此,证明了肿瘤细胞的高效摄取,这有利于将其应用于肿瘤靶影像中。膀胱起始的高CT值表明,GSH保护的金纳米团簇能渗透肾组织,通过膀胱排泄。肾的加强对比表明其有可能应用于探测肾的病变和损伤。

To assess the feasibility of ultra-small GSH-protected Au nanoclusters （NCs） employed as X-ray computed tomography （CT） contrast agent and study the effects of efficient uptake and clearance, CT values and time-dependent two- and three-dimensional images were recorded. The CT values of tumor region showed that the enhanced comparison gradually increased with the time. And the high enhanced comparison can also be reflected by distinct images until 6 h later. Therefore, high uptake of cancerous cell was proved by the CT values and two/three-images, which contributes to the application of Au NCs in tumor target imaging. High CT values of bladder were detected from the beginning, showing that Au NCs can permeate kidney tissue and be cleared by bladder. And the enhancement comparison of kidney revealed the possible application of exploration damage and lesion as probe.