艾司西酞普兰合并无抽搐电休克治疗自杀未遂抑郁症疗效观察

Efficiency of modified electroconvulsive therapy combined with escitalopram for depression with attempted suicide

目的探讨艾司西酞普兰合并无抽搐电休克(MECT)治疗自杀未遂抑郁症患者的疗效。方法将68例自杀未遂的抑郁症患者随机分为研究组35例和对照组33例,研究组予以艾司西酞普兰合并MECT治疗,对照组单用艾司西酞普兰治疗,共观察28 d,分别于治疗前及治疗后第3、7、14、21、28天予以汉密尔顿抑郁量表17项(HAMD-17)和贝克自杀意念量表(BSI)评定。结果研究组HAMD、BSI评分在治疗后第3天起即较治疗前显著下降(P<0.05),而对照组则在治疗后第7天起较治疗前显著下降(P<0.05)。研究组在治疗后各个评分点HAMD、BSI评分均低于对照组(P均<0.05)。结论艾司西酞普兰合并MECT治疗自杀未遂抑郁症患者疗效确切,起效快,优于单用艾司西酞普兰治疗。

Objective To explore the efficiency of modified electroconvulsive therapy （MECT） combined with escitalopram in the treatment of depression with attempted suicide. Methods 68 depressed patients with attempted suicide were randomized into study group （35 cases ） treated with MECT combined with eseitalopram and control group （33 cases ） treated with escitalopram monotherapy for 28 days. All patients were assessed with 17-item Hamilton Depressive Scale （ HAMD-17 ） and Beck Scale for Suicide Ideation （BSI） at the baseline and at the 3rd, 7th, 14th, 21th, 28th day of the treatment. Results Compared with baseline, scores of HAMD-17 and BSI decreased significantly from the 3rd day in study group （P 〈0.05） , while from the 7th day in control group （ P 〈 0.05 ）. Scores of HAMD-17 and BSI in study group were significantly lower than those in control group at each post-treatment interview （ P 〈 0.05 ）. Conclusion Compared with escitalopram monotherapy, MECT combined with escitalopram has better efficiency and takes effect more quickly in the treatment of depression with attempted suicide.