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干细胞改善肾脏缺血/再灌注损伤机制的研究进展 被引量:2

The Research Progress of the Mechanisms of Stem Cells Improving Renal Ischemia-reperfusion Injury
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摘要 肾脏缺血/再灌注损伤是导致急性肾损伤最常见的原因,它是一个多因素参与的病理生理过程,并对自体肾和移植肾急性损伤的愈后产生重要影响。由于肾脏缺血/再灌注损伤和急性肾损伤具有高发病率,且目前仍缺乏十分有效的治疗手段,因此迫切需要寻找一种有效的治疗方法。干细胞是一类具有多向分化潜能的细胞,具有能够自我更新和分化为多种细胞的能力,现有的研究证实干细胞疗法可减轻肾脏缺血/再灌注损伤,因此干细胞疗法为治疗肾脏缺血/再灌注损伤提供了新方法。 Ischemia-reperfusion injury(IRI) remains one of the leading causes of acute kidney injury (AKI). IRI is an underlying multifactorial pathophysiological process which affects the outcome of the acute renal injury after both autologous and transplanted patients. The high morbidity associated with IRI/AKI and disappointing results from current available clinical therapeutic approaches prompt further research. Stern ceils are undifferentiated ceils that can undergo both renewal and differentiation into one or more eel1 types which can ameliorate IRI. Existing research confirmed that stem cell transplantation can ameliorate renal IRI, therefore provide a novel way for the treatment of kidney renal IRI.
出处 《医学综述》 2014年第17期3114-3116,共3页 Medical Recapitulate
关键词 干细胞 缺血/再灌注损伤 急性肾损伤 肾移植 Stem cells Ischemia-reperfusion injury Acute renal injury Kidney transplantation
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  • 1Giraud S,Favreau F, Chatauret N, et al. Contribution of large pig for renal ischemia-reperfusion and transplantation studies: the prechnical model[ J]. J Biomed Bioteehno1,2011,2011:532127.
  • 2Jang HR, Ko GJ, Wasowska BA, et al. The interaction between ischemia-reperfusion and immune responses in the kidney [ J ]. J Mol Med,2009,87(9) :859-864.
  • 3van der Woude FJ, Schnuelle P, Yard BA. Preconditioning strate- g4es to limit graft immunogenieity and cold ischemic organ injury [ J ]. J Investig Med,2004,52 (5) :323-329.
  • 4Metealfe M, Butterworth P, White S, et al. A case control comparison of the results of renal transplantation from heart-beating and non heart-beating donors [ J ]. Transplantation ,2001,71 ( 11 ) : 1556-1559.
  • 5Semedo P, Palasio CG, Oliveira CD, et al. Early modulation of inflammation by mesenchymal stem eel] after acute kidney injury [ J]. Int Immunopharmacol,2009,9(6) :677-682.
  • 6Sdenz-Morales D, Eseribese MM, Stamata-kis K, et aL Require- ments for proximal tubule epithelial cell detachment in response to ischemia: role of oxidative stress [ J]. Exp Cell Res, 2006,312( 19 ) :3711-3727.
  • 7Chow WH, Dong LM, Devesa SS. Epidemiology and risk factors for kidney cancer [ J ]. Nat Rev Urol,2010,7 (5) :245-257.
  • 8Furuichi K, Shintani H, Sakai Y, et al. Effects of adipose-derived mesenchymal cells on ischemia-reperfusion injury in kidney [ J ]. Clin Exp Nephrel,2012,16 (5) :679-689.
  • 9Reinders ME, Rabelink TJ. Adipose tissue-derived stem cells : can impure cell preparations give pure results[J]. Nephrol Dial Trans- plant,2010,25 ( 12 ) : 3874-3884.
  • 10Brodsky S, Kim B, Yamamoto T, et al. Endothelial dysfunction in acute renal ischemia: rescue by' transplanted endothelial cells [ J ]. Am J Physiol Renal Physiol, 2002,16 ( 5 ) : F1140-F1149.

同被引文献49

  • 1Slegtenhorst BR,Dor FJ,Rodriguez H,et al.Ischemia/reperfusion injury and its consequences on immunity and inflammation[J].Curr Transplant Rep,2014,1(3):147-154.
  • 2Gong H,Sun J,Xue W,et al.Protective effect of truncated Na+/K+-ATPaseβon ischemia/reperfusion-induced renal injury in rats[J].Exp Biol Med,2014,239(6):677-685.
  • 3Jani A,Epperson E,Martin J,et al.Renal protection from prolonged cold ischemia and warm reperfusion in hibernating squirrels[J].Transplantation,2011,92(11):1215-1221.
  • 4Ponticelli C.Ischaemia-reperfusion injury:a major protagonist in kidney transplantation[J].Nephrol Dial Transplant,2014,29(6):1134-1140.
  • 5Snoeijs MG,Dekkers AJ,Buurman WA,et al.In situ preservation of kidneys from donors after cardiac death:results and complications[J].Ann Surg,2007,246(5):844-852.
  • 6Oniscu GC,Randle LV,Muiesan P,et al.In situ normothermic regional perfusion for controlled donation after circulatory death:the United Kingdom experience[J].Am J Transplant,2014,14(12):2846-2854.
  • 7Lee JH,Hong SY,Oh CK,et al.Kidney transplantation from a donor following cardiac death supported with extracorporeal membrane oxygenation[J].J Korean Med Sci,2012,27(2):115-119.
  • 8Kim SM,Ahn S,Min SI,et al.Cold ischemic time is critical in outcomes of expanded criteria donor renal transplantation[J].Clin Transplant,2013,27(1):132-139.
  • 9Zeng M,Wei X,Wu Z,et al.Reactive oxygen species contribute to simulated ischemia/reperfusion-induced autophagic cell death in human umbilical vein endothelial cells[J].Med Sci Monit,2014,20:1017-1023.
  • 10Nakagawa K,Koo DD,Davies DR,et al.Lecithinized superoxide dismutase reduces cold ischemia-induced chronic allograft dysfunction[J].Kidney Int,2002,61(3):1160-1169.

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