摘要
肾脏缺血/再灌注损伤是导致急性肾损伤最常见的原因,它是一个多因素参与的病理生理过程,并对自体肾和移植肾急性损伤的愈后产生重要影响。由于肾脏缺血/再灌注损伤和急性肾损伤具有高发病率,且目前仍缺乏十分有效的治疗手段,因此迫切需要寻找一种有效的治疗方法。干细胞是一类具有多向分化潜能的细胞,具有能够自我更新和分化为多种细胞的能力,现有的研究证实干细胞疗法可减轻肾脏缺血/再灌注损伤,因此干细胞疗法为治疗肾脏缺血/再灌注损伤提供了新方法。
Ischemia-reperfusion injury(IRI) remains one of the leading causes of acute kidney injury (AKI). IRI is an underlying multifactorial pathophysiological process which affects the outcome of the acute renal injury after both autologous and transplanted patients. The high morbidity associated with IRI/AKI and disappointing results from current available clinical therapeutic approaches prompt further research. Stern ceils are undifferentiated ceils that can undergo both renewal and differentiation into one or more eel1 types which can ameliorate IRI. Existing research confirmed that stem cell transplantation can ameliorate renal IRI, therefore provide a novel way for the treatment of kidney renal IRI.
出处
《医学综述》
2014年第17期3114-3116,共3页
Medical Recapitulate
关键词
干细胞
缺血/再灌注损伤
急性肾损伤
肾移植
Stem cells
Ischemia-reperfusion injury
Acute renal injury
Kidney transplantation