复方阿嗪米特联合伊托比利治疗胃癌化疗后腹胀的临床研究

Study on the Clinical Effect of Azintamide Combined with Itopride Hydrochloride in the Treatment for Abdominal Distention after Gastric Cancer Chemotherapy

目的观察复方阿嗪米特肠溶片联合伊托比利对胃癌化疗后出现腹胀的疗效。方法将胃癌化疗后腹胀患者138例纳入本研究。试验组予以复方阿嗪米特肠溶片2粒,每日3次,盐酸伊托比利50 mg,每日3次,疗程4周,对照组仅给予盐酸伊托比利50 mg,每日3次,疗程4周,观察治疗前后腹胀症状积分改变。结果复方阿嗪米特肠溶片联合盐酸伊托比利可明显改善胃癌化疗后的腹胀症状,治疗1周、2周、3周及4周腹胀症状积分均显著地下降(P<0.05),且优于单用盐酸伊托比利组。结论复方阿嗪米特肠溶片联合伊托比利治疗胃癌化疗后腹胀明显有效,且较单用伊托比利效果好。

Objective To observe the effect of compound azintamide enteric-coated tablets combined with itopride hydmchloride in the treatment for abdominal distention after gastric cancer chemotherapy. Methods A total of 138 cases of gastric cancer patients with abdominal distension after chemotherapy were selected for this study. Patients in the observation group were given 2 compound azintamide enteric-coated tablets at a time,three times daily,and 50 mg of itopride hydrochloride at a time,3 times a day,for 4 weeks; while patients in the control group were given only 50 mg of itopride hydrochloride at a time, three times a day,for g weeks. The score changes of the abdominal distension symptom were observed before and after treatment. Results Compound azintamide enteric-coated tablets combined with itopride hydrochloride can significantly improve the symptoms of abdominal distention after gastric cancer chemotherapy, the abdominal distension symptom scores after 1 week, 2 weeks, 3 weeks and 4 weeks of the treatment were significantly decreased （ P 〈 0.05 ）, and better than the control group. Conclusion The curative effect of compound asintamide enteric-coated tablets combined with itopride hydrochloride in treating the abdominal distension after gastric cancer chemotherapy is remarkable, and is better than the single therapy of itopride hydrochloride.