辛伐他汀联合银杏达莫治疗急性脑梗死的疗效观察

Observation of Therapeutic Effect of Simvastatin Combined with Yinxingdamo on Treatment of Acute Cerebral Infarction

目的观察辛伐他汀联合银杏达莫治疗急性脑梗死的临床疗效。方法选取2008年8月至2013年2月在武警湖北总队医院住院治疗的52例急性脑梗死患者,按随机数字表法分为两组,辛伐他汀联合银杏达莫组(联合银杏达莫组)27例,在常规治疗基础上加用辛伐他汀(20 mg/d,口服)联合银杏达莫(20 mL+生理盐水250 mL,静脉滴注,每日1次)治疗;辛伐他汀组,25例,在常规治疗基础上仅加用辛伐他汀治疗(20 mg/d,口服,每日1次),比较两组临床疗效、神经功能缺损程度及生活能力改善情况。结果联合银杏达莫组治疗总有效率(85.2%)显著地高于辛伐他汀组(72.0%)(P<0.05);辛伐他汀联合银杏达莫组和辛伐他汀组治疗后神经功能缺损评分(15.1±4.8,19.3±5.5)及生活能力(3.04±0.67,3.89±0.81)等级评分较治疗前(26.7±7.5,26.2±7.8;5.62±1.32,5.68±1.36)均显著下降(P<0.05),辛伐他汀联合银杏达莫组较辛伐他汀组下降更为显著(P<0.05)。结论辛伐他汀联合银杏达莫治疗急性脑梗死疗效显著,可明显改善患者的神经功能及生活能力。

Objective To observe the clinical effects of simvastatin combined with Yinxingdamo on treatment of acute cerebral infarction. Methods A total of 52 cases of patients with acute cerebral infarction who were hospitalized in Hubei Provincial Corps Hospital of Chinese People＇s Armed Police Forces from Aug. 2008 to Feb. 2013 were chosen and randomly divided into two groups based on random number table method. The Simvastatin combined with Yinxingdamo group （ n = 27 ） was treated by simvastatin combined with Yinxingdamo and conventional therapy （20 mL,250 mL saline infusion, IV once per day ） ; the simvastafin group （n = 25 ） was treated by simvastatin and conventional therapy（20 mg/d, orally once per day ）. The clinical efficacy,neurological deficits and improvement of the life skills of the two groups were compared. Results The total effective rate in the Simvastatin combined with Yinxingdamo group（85.2% ） was significantly higher than that in simvastatin group （72.0%） （ P 〈 0.05 ） ; after treatment, the degree of neurological deficits （ 15.1 ± 4.8,19.3 ± 5.5 ） and scores of life skills （ 3.04 ±0.67,3.89 ±0.81 ） were significantly decreased for both groups compared to those before treatment （26.7 ±7.5,26.2 ± 7.8 ; 5.62± 1.32,5.68 ± 1.36） （ P 〈 0.05 ）, the Simvastatin combined with Yinxingdamo group decreased more significantly than the simvastatin group（ P 〈 0.05 ）. Conclusion Simvastatin combined with Yinxingdamo on treatment of acute cerebral infarction showed notable therapeutic effects and it can significantly improve the patient＇s neurological function and life skills.