蚌埠地区多耐药肺结核患者近期治疗效果临床研究

Prevention and control program of multi-drug-resistant tuberculosis in Bengbu area: a clinical research on recent treatment effects

目的探讨蚌埠地区多耐药肺结核患者个体化治疗方案近期治疗效果,为进一步提高蚌埠地区耐药肺结核防治水平提供参考。方法依据我院肺结核病人登记本,对2011年4月-2012年3月在我院就医的425例耐药高危人群进行痰分支杆菌培养及药物敏感试验,根据药敏结果从中选择符合入项标准的多耐药患者36例。结果 36例入项患者,中途自动退项者6例,丢失率17%;实际完成疗程患者30例,其中临床治愈26例,治愈率87%;治疗失败4例。X线表现:病灶显著吸收21例,病灶吸收8例,病灶不变1例;伴有空洞者28例,空洞闭合者21例,空洞缩小者6例,空洞不变者1例。结论患者治疗效果与耐药数量密切相关,加强耐药患者管理,预防耐药病例发生和治疗耐药患者共抓,是有效控制耐药疫情的关键。

Objective To discuss the recent individualized treatment effects on multi-drug-resistant tuberculosis and pro-vide basis for further improvement in prevention and control of drug-resistant tuberculosis in Bengbu area .Methods Based on the registration of the tuberculosis patients in our hospital ,425 cases of drug-resistant high risk patients had been tested by the sputum mycobacterium culture and drug sensitivity test from April 2011 to March 2012.According to the results of drug suscep-tibility,36 suitable multi-drug-resistant patients had been chosen for the program .Results Of all the 36 cases,6 cases （17%） automatically quit in the midway.30 cases completed the course of treatment ,among which,26 cases （87%） were clinically cured and 4 cases failed.Image manifestation showed significant focus absorption in 21 cases,focus absorption in 8 and unchanged focus in one case;cavity closure in 21cases,cavity reduction in 6 and unchanged cavity in one case .Conclu-sion The treatment effect is closely related to the number of drug resistance .Enhancing management of drug-resistant pa-tients,preventing cases of drug-resistance and treating drug-resistant patients are keys to effective control of drug-resistant situ-ation.