hs-CRP NT-proBNP与冠状动脉病变程度的关系

The Relationship of hs- CRP NT- proBNP with the Degree of Coronary Artery Disease

目的:探讨hs-CRP、NT-proBNP对冠脉病变程度判断的价值。方法:将116例心内科患者根据冠脉造影确定冠脉病变支数分为单支组(39例)、双支组(40例)、三支组(37例),并选取40例健康体检者作为对照组,分别测定hs-CRP、NT-proBNP浓度,对其与冠脉病变程度采用Spearman相关性分析。结果:对照组、单支组、双支组、三支组NT-proBNP逐渐上升,组间差异比较有统计学意义(P<0.01);单支组、双支组、三支组hs-CRP均高于对照组(P<0.01),但三组组间比较差异无统计学意义(P>0.05);Spearman分析显示NT-proBNP与冠脉病变支数呈正相关(r=0.418,P<0.05),hs-CRP与冠脉病变程度无相关性。结论:NT-proBNP与冠脉病变程度呈正相关,可作为冠脉病变程度判断的可靠指标,hs-CRP与冠状动脉病变无相关性。

Objective：To investigate the value of hs-CRP ,NT-proBNP in the determination of coronary lesions .Method：116 cases of coronary heart disease patients were divided into single group （ 39 cases ） , double vessel group （ 40 cases ） , three vessel group（37 cases） according to coronary according to shadow and 40 cases of healthy volunteers as a control group ,were measured hs-CRP,NT-proBNP concentrations ,and its degree of coronary artery disease using Spearman correlation analysis . Result：In the control group ,the group of single ,double vessel group ,three vessel group , NT-proBNP gradually increased , The difference between the groups was statistically significant （P〈0.05）;hs-CRP of single group,double-vessel group, three vessel groups were higher than that in the control group （ P〈0.01） ,but the difference between the three groups was not statistically sig-nificant（P〉0.05）;Spearman analysis showed NT-proBNP count with coronary artery disease was positively correlated （r=0. 118,P〈0.05） ,There＇s no correlation between the degree of coronary artery disease and hs-CRP .Conclusion：NT-proBNP and severity of coronary artery disease is positively correlated , which can be used as a reliable indicator to determine the severity of coronary artery disease ,hs-CRP is not correlated with coronary artery disease .