肌酸激酶MB肌钙蛋白和白介素-6与有机磷中毒性心肌炎关系的探讨

Study on the Relationship between CK- MB TNI and IL- 6 and Organophosphate Toxic Myocarditis

目的:探讨有机磷中毒性心肌炎患者CK-MB、TNI、IL-6水平的变化情况。方法:选择本院有机磷中毒性心肌炎患者30例为研究对象,选择同期健康体检者30例为对照组,两组患者均空腹抽静脉血3mL,送实验室检测患者CK-MB、TNI、IL-6水平,并进行组间比较。结果:中毒组患者CK-MB、TNI、IL-6水平明显高于对照组,两组比较差异有统计学意义(P<0.05);中毒患者由轻度到重度CK-MB、TNI、IL-6水平逐渐升高,各亚组间比较,差异有统计学意义(P<0.05)。结论:CK-MB、TNI作为心肌损伤的特异性标记物,能较好的反应中毒性心肌损害的程度,IL-6通过炎症反应引起心肌损伤,也可作为心肌损害程度的监测指标;三者联合可有效反映有机磷中毒性心肌损害程度,并指导治疗。

Objective：To investigate the changes of CK-MB, TNI and IL-6 levels in organophosphate toxic myocarditis patients .Method：30 cases of patients with organophosphate toxic myocarditis in our hospi-tal were selected , meanwhile another 30 cases of healthy people in the same period were selected as control group, 3mL blood was pumped in patients of two groups , and CK-MB, TNI and IL-6 levels were detected and compared between the two groups .Result：CK-MB, TNI and IL-6 levels of the poisoned group were sig-nificantly higher than those in control group ,the differences were statistically significant （P〈0.05）;from mild to severe, the CK-MB, TNI and IL-6 levels increased gradually , the differences were statistically significant between the subgroup（P〈0.05）.Conclusion： As specific markers of myocardial injury,CK-MB and TNI can better react the extent of myocardial damage toxic , IL-6 induce myocardial injury through inflammation , which can also be used as indicators for monitoring the extent of myocardial damage ;the combination of the three can effectively reflect the extent of myocardial damage by organophosphate , meanwhile guide the treat-ment.