老年肺炎患者血浆D-二聚体、白细胞检测的临床意义

Clinical Significance of Plasma D-dimer and White Blood Cell Detection in Elderly Patients with Pneumonia

目的研究血浆D-二聚体、白细胞(WBC)水平与老年肺炎的关系,探讨二者对老年肺炎的早期诊断及病情严重程度评估的临床价值。方法采用血细胞分析仪检测100例老年肺炎患者(肺炎组)治疗前、治疗14 d后和100例健康体检者(正常对照组)的WBC、血小板(PLT)和红细胞压积(HCT)水平。使用全自动血凝仪、采用免疫比浊法检测各组血浆D-二聚体水平。结果与正常对照组比较,肺炎组治疗前、治疗14 d后WBC、血浆D-二聚体水平均明显升高(均P<0.05);与治疗前比较,肺炎组治疗14 d后WBC、血浆D-二聚体水平均明显降低(均P<0.05);肺炎组治疗前、治疗14 d后HCT、PLT水平与正常对照组比较差异均无统计学意义(均P>0.05)。结论检测血浆D-二聚体和WBC水平,对老年肺炎的早期诊断及病情严重程度评估有重要的临床意义。

Objective To analyze the correlation of plasma D-dimer and white blood cell （WBC） levels with senile pneumonia,and to explore the value of plasma D-dimer and WBC detection in the early diagnosis of senile pneumonia and the assessment of illness severity. Methods The WBC,platelet （PLT） and hematocrit （HCT） levels were measured using hematology analyzer and D-dimer levels were determined by immunoturbidimetry using automatic coagulation analyzer before and after treatment for 14 days in the 100 elder pneumonia patients （pneumonia group） and the 100 health physical exam-ination（normal control group）. Results Compared with normal control group,WBC and D-dimer levels significantly increased in pneumonia group before and after treatment for 14 days （P〈0.05）. Compared with preoperative levels, WBC and D-dimer levels in pneumonia group significantly decreased after treatment for 14 days （P〈0.05）. There were no obvious differences in HCT and PLT levels before and after treatment for 14 days between the two groups （P〉0.05）. Conclusion The detection of plasma D-dimer and WBC levels has important clinical significance in the early diagnosis of senile pneumonia and the assessment of illness severity.