干细胞相关基因与肿瘤治疗

Stem Cell-related Genes and Cancer Therapy

肿瘤干细胞同样具有自我更新,繁殖的能力,并能够表达特定的干细胞标记。目前仍然不清楚肿瘤干细胞是来源于普通干细胞的变异还是由肿瘤细胞再分化为干细胞样的细胞。常规的治疗方法能够杀死多数的肿瘤细胞,但极少量肿瘤干细胞的存在即可造成肿瘤的复发。该文对肿瘤干细胞,干细胞相关基因,肿瘤干细胞分离等的问题进行了综述,并提出了简单的评论及发展趋势预测,为肿瘤的基因研究及临床治疗提供参考。

Similarly cancer stem cells have the ability of self-renewal and reproduction,and capable of expressing specific stem cell marker. It is still unclear whether cancer stem cells are derived from the mutation of ordinary stem cells or differentiated into stem-like cells by tumor cells. Conventional treatment methods can kill most tumor cells,but the presence of a very small amount of cancer stem cells can cause recurrence of the tumor. This paper reviewed on cancer stem cells,stem cell-related genes and cancer stem cells isolation and other issues. A simple comment and trends forecasting is made to provide reference for clinical research and cancer gene therapy.