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多囊卵巢综合征患者卵巢颗粒细胞COX-2和15-PGDH的表达研究

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摘要 目的研究COX-2和15-PGDH在PCOS患者卵巢颗粒细胞中的表达，探讨PCOS患者排卵障碍的分子机制。方法应用荧光半定量Real—time PCR检测35例行IVF—ET的PCOS患者（实验组）及同期40例因输卵管因素和／或男方因素行IVF—ET的患者（对照组）的卵巢颗粒细胞中COX-2和15-PGDH的mRNA表达的差异。结果实验组COX-2 mRNA的相对表达7倍于对照组，差异有统计学意义（P〈0．001）；实验组15-PGDH mRNA的相对表达是对照组的0．60倍，差异有统计学意义（P〈0．05）。结论COX-2和15-PGDH的差异表达可能与PCOS发病机制相关。
作者 刘海英 麦紫欣 刘见桥
机构地区 广州医科大学附属第三医院生殖医学中心广东省生殖与遗传重点实验室
出处 《国际医药卫生导报》 2014年第20期3083-3085,共3页 International Medicine and Health Guidance News
关键词 COX-2 15-PGDH 颗粒细胞 多囊卵巢综合症(PCOS)
分类号 R711.75 [医药卫生—妇产科学]
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参考文献12

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二级参考文献28

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国际医药卫生导报
2014年 第20期

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