CASP 8基因-6526NI/D多态性与2型糖尿病易感性的关系

The study on CASP 8-652 6N I / D polymorphism and susceptibility of 2 type diabetes mellitus

目的：分析半胱氨酸蛋白酶8（CASP8）基因-6526NI／D多态性与2型糖尿痛（T2DM）易感性的关系。方法：采用PCR—RFLP技术结合DNA测序检测414例正常人和410例2型糖尿患者CASP8基因-6526NI／D的多态性。结果：对照组和糖尿病组I／I、I／D和D／D的基因型频率分别为56．5％、38．9％、4．6％和58．0％、32．9％、9．0％．差异有统计学意义（P〈0．05）。D／D基因型发生T2DM的风险为I／I基因型的1．916倍（95％CI=1．199-3．054，P〈0．05）。D／D基因型的空腹血糖高于I／D和I／I基因型（P〈0．05）。结论：CASP8基因-6526NI／D多态性与2型糖尿病的发生相关。

Objective To investigate the association of cysteine aspartic acid specific protease 8 （CASP 8） gene-652 6N Insertion/Deletion polymorphisms and susceptibility of type 2 diabetes meUitus （T2DM）. Methods CASP 8 gene -652 6N I/D polymorphisms were detected by polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing in 414 controls and 410 patients with T2DM. Results I/I, I/D and D/D genotype frequency were 56.5%, 38.9%, 4.6% in controls and 58.0%, 32.9%, 9.0% in T2DM group respectively （P 〈 0.05）. The risk in D/D genotype people was 1.916 times than I/I genotype （adjusted OR = 1.916, 95%CI = 1.199 - 3.054, P 〈 0.05）. The fasting blood sugar of D/D genotype people was significantly higher than that of I/D and I/I genotype people （P 〈 0.05）. Conclusions CASP 8 gene -652 6N I/D polymorphisms are associated with T2DM outbreak.