孕晚期妊娠糖尿病脂联素、瘦素、抵抗素水平与胰岛素抵抗的相关性研究

Correlation between levels of adiponectin,leptin,resistin and insulin resistance in gestational diabetes mellitus during third trimester

目的观察孕晚期妊娠糖尿病(GDM)患者的脂联素(ADP)、瘦素(LEP)、抵抗素水平及其与胰岛素抵抗(IR)的相互关系。方法选取2013年3月—2014年3月孕晚期GDM患者64例设为观察组,同期口服葡萄糖耐量试验正常的妊娠期妇女60例设为对照组,观察2组脂代谢相关指标、血ADP、LEP、抵抗素水平的差异及其与胰岛素抵抗指数(IRI)的相关性。结果观察组ADP水平显著低于对照组(P<0.01),LEP、抵抗素水平及IRI显著高于对照组(P<0.01)。相关性分析发现,ADP与IRI显著负相关,抵抗素与IRI显著正相关(P<0.01)。结论妊娠晚期GDM患者的血LEP、抵抗素水平显著上升,ADP水平显著下降,LEP和抵抗素是影响IR的独立危险因子。

Objective To observe the relationship between levels of adiponectin（ADP）,lep-tin（LEP）,resistin and insulin resistance （IR）in the third trimester of gestation diabetes mellitus （GDM）patients.Methods 64 GDM patients were selected as observation group,while 60 normal pregnancy women without GDM were collected as control group.Differences of lipid metabolism related indexes,serum ADP,LEP,resistin levels between two groups were observed and analyzed for the cor-relation with insulin resistance index （IRI）.Results Level of ADP in observation group was signifi-cantly lower than the control group （P〈0.01 ）,LEP,resistin and IRI were significantly higher than those in the control group （P〈0.01）.Correlation analysis showed ADP was negatively correlated with IRI and positively correlated with resistin and IRI （P〈0.01 ）.Conclusion Increasing of LEP,re-sistin and decreasing of ADP potentially shows a correlation with insulin r＆#233;sistance in GDM patients during third trimester,and LEP and resistin are two potential independent risk factors of IR.