应用头孢菌素后饮酒致双硫仑样反应30例临床分析

After Application of Cephalosporin-induced Disulfiram-like Alcohol Reactions of 30 Cases

目的探讨应用头孢菌素后饮酒致双硫仑样反应的发病机制及治疗方法,以引起临床医师的注意,避免其发生。方法观察30例病例的临床表现、治疗及转归,对双硫仑样反应的发病机制、防治措施进行探讨。结果 24例轻、中度患者给予对症处理后症状缓解,6例重度患者,静注纳洛酮2-4 mg,地塞米松5-10 mg,症状均于3-4 h内缓解。结论临床医师只要对双硫仑样反应有足够的认识和重视,加强预防,诊治正确,预后良好。

Objective To investigate the cephalosporin after alcohol-induced disulfiram-like reaction in the pathogenesis and treatment, to attract the attention of clinicians that, to avoid its occurrence. Methods Observed 30 cases of clinical manifestations, treatment and prognosis of disulfiram-like reaction in the pathogenesis, prevention and control measures were discussed. Results 24 cases of patients with mild to moderate for the symptomatic relief of symptoms after treatment, six cases of severe disease, intravenous naloxone 2-4 mg dexamethasone 5-10 mg, symptoms were 3-4 h mitigation. Conclusion Clinical doctors as long as on the double sulfur hebron sample reaction have enough knowledge and value, strengthening prevention, correct diagnosis and treatment, prognosis is good.