米索前列醇联合缩宫素预防和治疗产后出血的临床观察

Clinical Observation of Misoprostol Combined with Oxytocin in Prevention and Treatment of Postpartum Hemorrhage

目的探讨米索前列醇联合缩宫素预防和治疗产后出血临床疗效。方法选取我院2013年1月至2014年1月住院治疗产后出血患者80例,按照随机对照的原则,将患者分为两组,观察组和对照组,每组各40例,观察组给予米索前列醇与缩宫素联合治疗,而对照组仅给予缩宫素治疗,观察两组产后2 h、产后24 h出血量、产后出血发生率以及不良反应发生情况。结果观察组产后2 h、产后24 h出血量明显少于对照组,差异显著,具有统计学意义(P<0.05),观察组产后出血发生率明显低于对照组,差异显著,具有统计学意义(P<0.05),两组均未发生不良反应。结论米索前列醇联合缩宫素预防和治疗产后出血效果显著,能够有效的降低产后出血量,具有临床应用价值。

Objective To investigate the clinical efficacy of misoprostol combined with oxytocin in the prevention and treatment of postpartum hemorrhage. Methods 80 patients with postpartum hemorrhage in our hospital from January 2013 to January 2014 were randomly divided into observation group and the control group, 40 cases in each group, the patients in the observation group were given misoprostol and oxytocin, while patients in the control group were only given oxytocin treatment, the amount of bleeding of 2 hours, 24 hours after delivery, the incidence rate of postpartum hemorrhage and adverse reactions. Results The amount of bleeding of 2 hours, 24 hours after delivery in the observation group was significantly lower than those in the control group （P〈0.05）, the incidence rate of postpartum hemorrhage in the observation group was significantly lower than that in the control group （P〈0.05）, there was no adverse reaction in two groups. Conclusion The clinical efficacy of misoprostol combined with oxytocin in the prevention and treatment of postpartum hemorrhage is significant, this treatment plan can effectively reduce the amount of postpartum hemorrhage, has the value of clinical application.