噻托溴铵对稳定期中、重度COPD患者肺功能和运动耐量的影响

Effect of Tiotropium Bromide on Lung Function and Exercise Tolerance of Moderately Severe COPD Patients in Steady Stage

目的观察噻托溴铵对稳定期中、重度COPD患者肺功能和运动耐量的影响,探讨其临床治疗稳定期中、重度COPD的疗效。方法对我院67例诊断为稳定期中、重度COPD患者进行随机分组用药干预研究,观察组采用噻托溴铵干粉吸入,对照组采用异丙托溴铵气雾剂吸入,对患者进行为期1个月的临床治疗。检测治疗前后两组患者的肺功能以及运动耐量的变化。结果与治疗前相比,两组患者的肺功能和运动耐量均有了一定的好转。观察组与对照组相比,前者肺功能和运动耐量的改善明显优于后者(P<0.01)。结论噻托溴铵干粉吸入对稳定期中、重度COPD患者有较好的临床疗效,较目前临床常用的托溴铵气雾剂有着更为可靠的改善肺功能及运动耐量的作用。

Objective To observe the effect of tiotropium bromide on lung function and exercise tolerance of moderately severe COPD patients in steady stage and discuss its clinical effect. Method 67 cases of moderately severe COPD patients in steady stage were randomly divided, intervened by medication and analyzed. Observation group was treated by dry power inhalation of tiotropium bromide and control group was treated by aerosol inhalation of ipratropium bromide. The treatment course was 1 month. Lung functions and exercise tolerance changes of both groups before and after treatment were tested. Result Compared with prior treatment, lung functions and exercise tolerance of both groups improved and observation group was more significant （P〈0.01）. Conclusion Dry power inhalation of tiotropium bromide has a good effect for moderately severe COPD patients in steady stage, it has a more reliable function in improving lung function and exercise tolerance than aerosol inhalation of ipratropium bromide.