氨基己酸湿敷治疗难治性渗出性皮肤病

Aminocaproic acid wet dressing in treatment of refractory exudative dermatosis

目的探讨氨基己酸湿敷快速治疗难治性渗出性皮肤病患者的有效性和安全性。方法将难治性渗出性皮肤病患者20例随机分为实验组与对照组,每组10例,实验组用8%氨基己酸生理盐水湿敷治疗患处,对照组用0.1%依沙吖啶溶液湿敷治疗患处。结果实验组渗出停止时间(3.50±1.58)天,10例均有效;而对照组10例均无效,二者有效构成比用Fisher确切概率法检验有显著性差异(P<0.001);两组治疗期间均未发现不良反应。结论 8%氨基己酸湿敷治疗难治性渗出性皮肤病有效而安全。

Objective To investigate the efficacy and safety of treatment of patients with refractory exudative dermatosis by aminocaproic acid wet quickly. Methods Twenty patients with exudative dermatosis were randomized into experimental group and control group,each group with 10 cases. The experimental group were treated with 8% aminocaproic acid saline wet dressing on the affected area. The control group used 0. 1% ethacridine solution wet compress to treat the affected area. Results In the experimental group,exudation stop time was（ 3. 50 ±1. 58） days,10 paitients were effective; while in the control group,10 patients were invalid,and there was significant difference with Fisher＇s exact probability in effectively constitutent ratio between both methods（ P〈 0. 001）. There was no adverse reaction in both experimental group and control group during treatment. Conclusion 8% aminocaproic acid wet compress is effective and safe in treatment of refractory exudative dermatosis.