基于改进的视觉CPT范式对注意缺陷多动障碍患儿额区ERPs的研究

The Study on Frontal ERPs Based upon Improved Visual CPT Paradigm in Children with Attention Deficit Hyperactivity Disorder

采用事件相关电位(ERPs)来研究注意缺陷多动障碍(ADHD)患儿在选择注意任务下额区的神经活动。实验采用高密度的脑电采集仪来记录受试在执行改进的视觉持续性操作测试(Visual-CPT)范式下的ERPs,12名患儿(ADHD组)及13名健康儿童(对照组)参加本次试验。在Go和No-go条件下,分别对两组受试的行为学及ERPs进行分析和比较,并对结果进行双样本t检验。结果发现,ADHD组在实验过程中表现得较差,漏报率和错误率明显增加,而且反应时间明显延长;无论是Go条件还是No-go条件,潜伏期未见显著性差异,但是ADHD组相比对照组在额区表现出幅值显著低的N2成分(P<0.05);此外,ADHD组在No-go条件下具有幅值显著高的P2成分(P<0.05)。结果表明,ADHD患儿在认知功能执行中产生障碍,而这种障碍可能与其额叶区域的ERPs波形幅值异常有关。

The event-related potentials （ERPs） coming from children hyperactivity disorder （ADHD） were analyzed in this paper, aiming who were diagnosed as attention-deficit to investigate the neural activity in the frontal lobe, when the children performed a selective attention task. A high density electroencephalogram （EEG） acquisition instrument was utilized to record the ERPs of subjects and an improved visual continuous performance test （Visual-CPT） was used as the experimental paradigm. Twelve diseased children （ADHD group） and 13 healthy children （Control group） participated the experiment. The behavior and ERPs results were analyzed and compared with a two-sample T-test between two groups under Go and No-go conditions. Results show that： 1 ） The ADHD group performed a poor task in the current study, with a higher missing rate and false alarm rate as well as a longer reaction time than control group; 2） Under both Go and No-go conditions, there were no significant difference observed in the ERPs latency. However, comparing with the control group, ADHD group has a lower N2 amplitude in frontal region （P 〈 0. 05） ; 3） In addition, the ADHD group show a higher P2 amplitude under the condition of No-go （P 〈 0.05）. The result indicates that childrenwith ADHD have a disorder in cognitive function implementation, and this impairment may be associated with the abnormal ERPs amplitudes in frontal lobe.