急性肝衰竭动物模型的研究进展

Recent advances in research on animal models of acute hepatic failure

急性肝衰竭是一种伴随多种临床症状的严重肝损伤疾病,死亡率高,治疗难度大,因此制备急性肝衰竭动物模型以进行治疗研究就显得非常必要。本文综述了适用于不同种类实验动物的急性肝衰竭模型的制备方法。

Acute hepatic failure （AHF） is a severe liver disease associated with a variety of clinical symptoms . AHF is difficult to treat and with a high mortality rate.Therefore, it is necessary to establish animal models of AHF for the investigation of therapy.In this article, the preparation methods of AHF animal models are reviewed which are applicable to different types of animals.