微钙化与易损斑块相关性的研究进展

Relationship between microcalcifications and vulnerable plaques:research progress

不良心血管事件(ACE)的发生,大部分是在动脉管腔轻至中度狭窄的基础上,由易损斑块破裂或侵蚀以及血栓形成所致。现代医学对冠状动脉粥样化性疾病的研究,已从以往仅关注管腔狭窄的程度向关注斑块的易损性转变。因此,探索易损斑块破裂的机制,早期识别易损斑块,预防ACE的发生成为心血管疾病研究领域的热点之一。近年来,大量研究发现动脉粥样硬化(AS)斑块内微钙化(microcalcifications,μCalcs)的出现与斑块的易损性关系密切,由此推测μCalcs可能是引起斑块破裂的一个重要因素。本文对AS斑块内μCalcs与易损斑块的相关性作一综述。

The occurrence of adverse cardiovascular events （ACE） is often due to vulnerable plaque rupture or thrombus formation on the basis of mild to moderate arteriostenosis. The research field for coronary artery disease has converted from the degree of luminal stenosis to the vulnerability of plaques. Therefore, exploring the meehanism of vulnerable plaque rupture, early identifying vulnerable plaques and preventing ACE have become the ＂hot spots＂ in the research field of cardiovascular diseases. In recent years, numerous studies have found that microcalcifications （μCalcs） are associated with plaque vulnerability, indieating that μCalcs may play an important role in plaque rupture. In this article we reviewed the relationship between microcalcifications and plaque vulnerability.