眼性前庭诱发肌源性电位与运动病易感性

Ocular Vestibular Evoked Myogenic Potentials and Motion Sickness Susceptibility

目的研究眼性前庭诱发肌源性电位(oVEMP)参数与运动病易感性的相关性。方法对31名运动病(MS)易感者与23名运动病非易感者进行oVEMP测试。采用受试者自评、运动病易感性问卷(MSSQ)与汉密尔顿焦虑量表(HAS)对运动病易感性进行评估。结果所有受试者均记录到双侧oVEMP反应。易感者与非易感者的MSSQ及HAS分数分别是18.27±5.23与2.34±1.21以及28.12±6.53与2.34±1.45。MS易感者与非易感者组间MSSQ与HAS分值存在显著差别。MS易感者与非易感者组间在oVEMP的N10与P15潜伏期、N10-P15间期、N10-P15波间幅度上未有显著差别。然而,同MS非易感者组相比,易感者组在oVEMP波间幅度双侧不对称比上存在增大的趋势(18.55±10.24%相对13.25±9.47%),尽管并没有达到统计显著性。结论 oVEMP结果与MS易感性间不存在相关性。易感者与非易感者组相比在oVEMP波间幅度双侧不对称比上存在增大的趋势。

To study the relationship between the ocular vestibular evoked myogenic potential（ oVEMP） and motion sickness susceptibility（ MSS）. Methods The oVEMP tests were performed on 31 MS susceptible and23 nonsusceptible individuals. MSS was determined with self-declaration,MSS questionnaire（ MSSQ） and Hamilton Anxiety Scale（ HAS）. Results Bilateral oVEMP responses were obtained in all subjects. HAS and MSSQ scores between the susceptible and nonsusceptible groups were 18. 27 ± 5. 23 vs. 2. 34 ± 1. 21 and28. 12 ± 6. 53 vs. 2. 34 ± 1. 45,respectively. Statistically significant differences in MSSQ and HAS scores were found between the moition sickness（ MS） susceptible and nonsusceptible groups. No difference was found between MS susceptible and nonsusceptible subjects in N10 and P15 wave latencies,N10-P15 interval,and peak-to-peak N10-P15 amplitude. However,there was a trend toward greater asymmetry ratio in the interpeak amplitude of MS susceptible group than of MS nonsusceptible group [（ 18. 55 ± 10. 24） % vs.（ 13. 25 ± 9.47） % ],although statistical significance was not reached. Conclusion It appears that no relation exists between oVEMP results and MS susceptibility. Nevertheless,the differences in the asymmetry ratios of oVEMP interpeak amplitudes between the two groups revealed a trend toward marginal statistical significance.