中性粒细胞与淋巴细胞比值在溃疡性结肠炎诊断及病情评估中的价值

Value of ratio of neutrophils to lymphocytes in diagnosis and evaluation of ulcerative colitis

目的探讨中性粒细胞与淋巴细胞比值(NLR)在溃疡性结肠炎(UC)诊断及病情评估中的价值。方法将UC组患者80例分为轻度(34例),中度(25例)及重度(21例)三组,对照组为结肠镜检查未示异常的健康人群60例。检测外周血血常规、C反应蛋白(CRP)和红细胞沉降率(ESR),计算NLR。采用受试者工作特征曲线(ROC)分析其在UC的初步诊断的灵敏度和特异度。结果 UC组患者的NLR、ESR和CRP均显著高于对照组(P<0.01);中度和重度患者NLR值较轻度患者升高明显(P<0.05)。三项指标中,NLR诊断UC效果较好。其ROC下面积为0.88(95%CI:0.85-0.92);当取2.02为截点时,NLR诊断UC的灵敏度和特异度分别为71%和68%。结论NRL对UC的临床初步诊断具有较高的敏感性和特异性,可作为评价UC病情的新指标。

Objective To investigate the value of ratio of neutrophils to lymphocytes（NLR） in the diagnosis and illness evaluation of ulcerative colitis（UC）. Methods A total of 80 patients with UC （group UC） was divided into mild（25 cases）,moderate（34 cases） and severe（21 cases）. Sixty healthy people（group C） were taken as the controls. Routine blood test, C-reactive protein（CRP） and erythrocyte sedimentation rate （ESR） were detected. NLR was calculated. The receiver operating curve（ROC） was used to analyze the sensitivity and specificity of NLR in primary diagnosis of UC. Results The levels of NLR,CRP and ESR were significantly higher in group UC than those in group C（P〈0. 01）. The NLR was higher in moderate and severe UC cases than that in the mild cases （P〈0. 05）. Among NLR, CRP and ESR, the NLR reported better sensitivity and specificity in preliminary diagnosis of UC. The area under ROC curve was 0. 88 （95% CI： 0.85-0.92） and the sensitivity and specificity were 71% and 68%, respectively, when 2.02 was taken as a cut-off value. Conclusion The NRL has better sensitivity and specificity for the preliminary clinical diagnosis of UC and may be taken as a new indicator in the diagnosis of UC.