硬膜外注射右美托咪定治疗带状疱疹后神经痛的效果观察

Efficacy of epidural dexmedetomidine in the treatment of postherpes neuralgia

目的:探讨右美托咪定硬膜外注射治疗带状疱疹后神经痛的临床效果。方法:40例患者随机分为观察组和对照组,各20例,分别接受硬膜外注射0.1%罗哌卡因10 ml+右美托咪定50μg+地塞米松2mg和0.1%罗哌卡因10 ml+地塞米松2 mg。比较两组治疗前后视觉模拟评分(VAS)以及CD4、CD8、CD4/CD8的变化。结果:治疗后3个月观察组VAS评分明显较对照组低,差异有统计学意义(P<0.01);观察组CD4/CD8显著高于对照组,差异有统计学意义(P<0.05)。结论:硬膜外注射右美托咪定治疗带状疱疹神经痛可有效地缓解疼痛,并对患者的免疫功能有一定的保护作用。

Objective ： To explore efficacy of epidural dexmedetomidine in the treatment of post-her- pes neuralgia. Methods： 40 psLtients with post-herps neuralgia were selected and randomly divided into two groups, 20 cases in each group. The observation group received epidural 10 m] 0. 1% ropiv- acaine ＋ dexmedetomidine 50 μg ＋2 mg dexamethasone, while the control group received epidural 10 ml 0.1% ropivacaine ＋ dexamethasone 2 rag. The CD4, CD8, CD4/CD8 and the scores of visual analogue scale （VAS） before and after treatment in the two groups were compared. Results： The scores of VAS in observation group after treatment was obviously lower than control group. The level of CD4/CD8 in observation group was obviously higher than that in the control group. Conclusion： Epidural dexmedetomidine could obviously induce pain and protect immune function in the treat- ment of post-herpes neuralgia.