白霉素联合沙丁胺醇布地奈德雾化吸入治疗毛细支气管炎的临床研究

Clinical research of Leucomycin combined with Salbutamol Budesonide atomization inhalation in the treatment of bronchiolitis

目的 探讨白霉素联合沙丁胺醇布地奈德雾化吸入治疗毛细支气管炎的临床效果。方法 选取承德市兴隆县妇幼保健院2011年10月~2013年10月诊治的毛细支气管炎患者228例,采用数字表随机法分为两组,114例患者采用沙丁胺醇布地奈德雾化吸入治疗为对照组,114例患者采用白霉素联合沙丁胺醇布地奈德雾化吸入治疗为观察组,比较两组患者的病症改善情况、临床疗效、不良反应情况。结果 观察组患者喘息消失时间、气促消失时间、肺部湿啰音消失时间、退热时间、咳嗽消失时间、呼吸困难消失时间、肺部哮鸣音消失时间、住院时间均明显短于对照组,观察组患者总有效率（98.2%）明显高于对照组（88.6%）,差异均有统计学意义（P〈0.05或P〈0.01）。观察组患者不良反应发生率为9.6%,对照组为7.9%,差异无统计学意义（P〉0.05）。结论 白霉素联合沙丁胺醇布地奈德雾化吸入疗法是治疗毛细支气管炎的有效方法,可明显改善患者的临床病症,临床疗效显著且安全性高,值得临床推广使用。

Objective To investigate clinical effect of Leucomycin combined with Salbutamol Budesonide atomization inhalation in the treatment of bronchiolitis. Methods Two hundred and twenty eight patients with bronchiolitis were se- lected in Maternal and Child Health Hospital of Xinglong County in Chengde City from October 2011 to October 2013, who were randomly divided into two groups. 114 patients treated with Salbutamol Budesonide atomization inhalation were as control group. 114 patients treated with Leucomycin combined with Salbutamol Budesonide atomization inhala- tion were as observation group. Symptoms improvement, clinical efficacy, adverse reactions were compared between two groups. Results Wheezing disappearance time, shortness breath disappearance time, pulmonary rales disappearance time, cooling time, cough disappearance time, breathing difficulties disappearance time, pulmonary wheezing disappear- ance time, hospitalization time in observation group were significantly shorter than control group, total effective rate （98.2%） in observation group was significantly higher than that of control group （88.6%）, the differences were statisti- cally significant （P 〈 0.05 or P 〈 0.01）. Incidence of adverse reactions in observation group was 9.6%, which of control group was 7.9%, the difference was not statistically significant （P 〉 0.05）. Conclusion Leucomycin combined with Salbutamol Budesonide atomization inhalation is an effective method in treatment of bronchiolitis, which can significant- ly improve clinical symptoms, has significant clinical effect and high security, which is worthy of clinical use.