福建省胃癌中低发地区发病相关影响因素流行病学调查

Epidemiological Survey on the Related Influencing Factors of Gastric Cancer Incidence in the Areas with Medium and Low Incidence,Fujian Province

目的为探索福建省居民胃癌发病危险因素提供线索。方法 2009年10月至2010年5月应用多阶段随机抽样法在厦门市的同安区和福安市抽取485人居民为调查对象,进行现场问卷调查,并检测血清PGⅠ、PGⅡ、G-17和Hp感染水平,比较两地胃癌发病相关影响因素的暴露特征。结果调查同安区居民272人,劳动强度、吸烟、吃热烫食品、吃薯干、饮茶频率均明显高于福安市(213人),饭量八分饱的比例和吃咸菜、水果、绿色蔬菜的频率均明显低于福安市(P<0.05);同安区居民血清PGI、PGⅡ水平均明显高于福安市,PGI/PGII水平明显低于福安市(均有P<0.05)。多因素Logistic回归分析显示,饭量、热烫食品、水果、绿色蔬菜、饮茶、血清PGⅠ、PGⅡ水平可能与两地胃癌发病水平有关。结论血清PGⅠ、PGⅡ可能是胃癌发病相关影响因素,在居民中开展血清PGⅠ、PGⅡ监测,并指导其改变不良的饮食习惯和生活方式,对预防胃癌发病有积极的现实意义。

Objective To provide clues for exploring the risk factors of gastric cancer incidence in Fujian province. Methods The subjects were selected randomly by multi-stage sampling method from Tongan district and Fuan city. The subjects received the interview questionnaires and detection of serum PG Ⅰ ,PG Ⅱ ,G-17, Hp . The exposure characteristics of related influencing factors of gastric cancer incidence in the two areas were compared. Results Labor intensity, smoking rates,the frequency of eating hot foods, dried sweet potatoes, tea were significantly higher in Tongan than in Fuan. The frequency of eating fruit,green vegetables and proportion of 80 % full meals were significantly lower in Tongan than in Fuan （both P 〈0.05）. The levels of PG Ⅰ , PG Ⅲ were significantly higher in Tongan district than in Fuan city while PG Ⅰ/PG Ⅱ ratio was significantly lower in Tongan district than in Fuan city （ P〈0.05）. Multivariate logistic re- gression analysis showed that food intake,hot food,fruit,green vegetables,tea,PG Ⅰ ,PG Ⅱ may be associated with gastric cancer incidence. Conclusion The serum PG Ⅰ ,PG Ⅱ may be the related influencing factors of gastric cancer. It is of positive practical significance for preventing gastric cancer to detect serum PG Ⅰ ,PG Ⅱ and change unhealthy eating habits and lifestyles.