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四氢喹啉-4-醇类衍生物的合成 被引量：1

Synthesis of 1,2,3,4-Tetrahydroquinolin-4-ol Derivatives
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摘要 以1,2,3,4-四氢喹啉为初始原料,经N-酰基保护、氧化、脱保护、还原等反应合成了一系列1,2,3,4-四氢喹啉-4-醇类的衍生物,总产率17%-41%,其结构经1H NMR和13C NMR确证。 A series of 1,2,3,4-tetrohydroquinolin-4-ol derivatives with overall yields of 17% -41% were synthesized from 1,2,3,4-tetrahydroquinoline by protection of NH group, oxidation, deprotee- tion and reduction reaction. The structures were confirmed by 1H NMR and 13C NMR.
作者 陈永正 郑代军 刘小卒 周晓建 徐可
机构地区 遵义医学院药学院
出处 《合成化学》 CAS CSCD 北大核心 2014年第5期687-690,共4页 Chinese Journal of Synthetic Chemistry
基金 国家自然科学基金资助项目(21162047 21262051) 贵州省科技厅资助项目(黔科合SZ字2012-3078号 黔科合人字2013-047)
关键词 四氢喹啉 氨基醇 四氢喹啉-4-醇 合成 tetrahydroquinoline alkamine tetrohydroquinolin-4-ol synthesis
分类号 O626.3 [理学—有机化学]
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参考文献11

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同被引文献19

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  • 8Bendale P, Olepu S, Suryadevara P K, et al. Second generation tetrahydroquinoline-based protein famesyl- transferase inhibitors as antimalarials [ J ]. J Med Chem, 2007,50 ( 19 ) :4585 - 4605.
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合成化学
2014年 第5期

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